assay
98%
optical activity
[α]25/D −17.0°, c = 2 in H2O
mp
192-195 °C (dec.) (lit.)
SMILES string
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
InChI
1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
InChI key
RWSXRVCMGQZWBV-WDSKDSINSA-N
正在寻找类似产品? 访问 产品对比指南
Application
生物抗氧化剂,已与抗肿瘤剂共同用于提高活性或者降低副作用。
可在5-10 mM下用于从谷胱甘肽琼脂糖洗脱谷胱甘肽S-转移酶(GST)。
Biochem/physiol Actions
作为内源性抗氧化剂在减少细胞代谢和呼吸爆发期间生成的活性氧方面发挥重要作用。 谷胱苷肽S-转移酶催化异生素、白三烯和其他亲电子分子生成谷胱苷肽硫醚。 谷胱苷肽也和蛋白质半胱氨酸残基形成二硫键。 经由这些机制,它会产生降低抗癌药功效的逆反效应(paradoxical effect)。
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Journal of the American Chemical Society, 116, 6537-6537 (1994)
J H Lee et al.
Cancer research, 54(9), 2398-2403 (1994-05-01)
7-N-((2-([2-(gamma-L-Glutamylamino)ethyl]dithio)ethyl))mitomycin C (KW-2149) is an analogue of mitomycin C (MMC) and has prominent activities against various tumors. We studied the antitumor effects of KW-2149 in MMC-resistant variants of human colon carcinoma HT-29 (HT-29/MMC) and mouse hepatoma Hepa-I (C4, B13NBii1) cells
J. Optim. Nutr., 2, 173-173 (1993)
Mario Faúndez et al.
Antimicrobial agents and chemotherapy, 52(5), 1837-1839 (2008-03-12)
L-buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused
Minakshi C Gurbhele-Tupkar et al.
Bioorganic & medicinal chemistry, 16(5), 2579-2590 (2007-12-11)
Almost all therapeutic proteins and most extracellular proteins contain disulfide bonds. The production of these proteins in bacteria or in vitro is challenging due to the need to form the correctly matched disulfide bonds during folding. One important parameter for
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持