G8503
18α-甘草次酸
≥95%
别名:
18α-甘草次酸, 18-异甘草次酸, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid
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关于此项目
经验公式（希尔记法）:
C30H46O4
化学文摘社编号:
分子量:
470.68
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352115
EC Number:
215-907-9
MDL number:
Assay:
≥95%
Quality Level
assay
≥95%
SMILES string
[H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O
InChI
1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1
InChI key
MPDGHEJMBKOTSU-PMTKVOBESA-N
General description
18α-甘草次酸 (18α-GA) 是一种在甘草中发现的具有生物活性的三萜类化合物。其显示对 11-HSD1（11-羟基类固醇脱氢酶 1）的选择性抑制。其对肝星状细胞 (HSC) 也有抗增殖和凋亡作用。
Application
18α-甘草次酸可用于合成：
- 3-酮-18α-甘草次酸
- 18α-甘草次酸甲酯
- 3-酮基-18α-甘草次酸甲酯
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Mohammad Shahidullah et al.
American journal of physiology. Cell physiology, 302(12), C1751-C1761 (2012-04-12)
In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens epithelium and show that TRPV4 activation is an important step in the response of
Sebastian M Goerke et al.
Tissue engineering. Part A, 18(23-24), 2395-2405 (2012-06-27)
Neovascularization represents an important issue in tissue-engineering applications, since survival of implanted cells strongly relies on sufficient oxygen and nutrient supply. We have recently observed that human bone marrow-derived mesenchymal stem cells (MSCs) support neovessel formation originating from coimplanted endothelial
Selective inhibition of 11?-hydroxysteroid dehydrogenase 1 by 18a-glycyrrhetinic acid but not 18?-glycyrrhetinic acid.
Classen-Houben D, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 113(3), 248-252 (2009)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G8503-250MG | 04061833644034 |
| G8503-1G | 04061833644027 |