产品名称
Cationic Liposomes for DNA/RNA delivery, DOTAP:DOPE (1:1) containing 0.5% Rhod-PE (Fluorescent)
contains
Rhod-PE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine
rhodamine B sulfonyl)) as fluorescent label
composition
Deionized RNAse-free Water
concentration
0.02 mM (Rhod-PE)
2 mM (DOPE)
2 mM (DOTAP)
impurities
1:1 mol/mol DOTAP:DOPE
particle size
100 nm
pH
7
absorbance ratio
560/583 nm
Quality Level
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Application
Drug delivery
Gene delivery
Lipid-protein interactions
Gene delivery
Lipid-protein interactions
Disclaimer
For research use only
General description
Cationic liposomes are traditionally used for the delivery of genetic materials such as various types of DNA (pDNA, cDNA, CpG DNA, oligonucleotide, antisense oligonucleotide), various types of RNA such as (siRNA, mRNA) and nucleic acid mimics (NAMs). The positive, cationic charge of the lipids is used to neutralize the negative charge of nucleic acids and results in greater encapsulation efficiency, cellular uptake and endosomal delivery.
Legal Information
Genesome is a trademark of Encapsula NanoSciences
Product of Encapsula Nanosciences
Preparation Note
Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.
Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.
Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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商品
LNPs are ideal carriers for mRNA drugs, as evident from the two FDA-approved SARS-CoV-2 vaccines. However, efficient LNPs need further research on ionizable lipid selection, formulation, and administration. This review examines lipid usage, ionizable lipid selection, and LNP design for mRNA drug delivery.
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