H23805
4-羟基香豆素
98%
别名:
4-羟基-1-苯并吡喃-2-酮
质量水平
方案
98%
mp
211-213 °C (lit.)
荧光
λem 373 nm in methanol
SMILES字符串
OC1=CC(=O)Oc2ccccc12
InChI
1S/C9H6O3/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5,10H
InChI key
VXIXUWQIVKSKSA-UHFFFAOYSA-N
基因信息
mouse ... Maoa(17161)
rat ... Aldh1a2(116676)
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警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Dharmesh H Mahajan et al.
Archiv der Pharmazie, 342(5), 281-290 (2009-05-06)
Novel 2-(coumarin-4-yloxy)-4,6-(substituted)-s-triazine derivatives i. e., diaryltriazine (DATA) are reported as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus HIV-1 (III-B), HIV-2 (ROD), and the double RT mutant HIV-1 (K103N and Y181C) were assessed.
Davorka Završnik et al.
Molecules (Basel, Switzerland), 16(7), 6023-6040 (2011-07-21)
We report on the synthesis of 4-hydroxycoumarin dimers 1-15 bearing an aryl substituent on the central linker and fused benzopyranocoumarin derivatives 16-20 and on their in vitro broad anti-DNA and RNA virus activity evaluations. The chemical identities and structure of
Benye Liu et al.
Plant molecular biology, 72(1-2), 17-25 (2009-09-17)
Coumarin forms in melilotoside (trans-ortho-coumaric acid glucoside)-containing plant species upon cell damage. In moldy melilotoside-containing plant material, trans-ortho-coumaric acid is converted by fungi to 4-hydroxycoumarin, two molecules of which spontaneously combine with formaldehyde to give dicoumarol. Dicoumarol causes internal bleeding
Katrin J Czogalla et al.
Blood, 122(15), 2743-2750 (2013-08-29)
Since the discovery of warfarin-sensitive vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), 26 human VKORC1 (hVKORC1) missense mutations have been associated with oral anticoagulant resistance (OACR). Assessment of warfarin resistance using the "classical" dithiothreitol-driven vitamin K 2,3-epoxide reductase (VKOR)
Mikael I Naumov et al.
The Journal of organic chemistry, 72(9), 3293-3301 (2007-03-29)
2-(methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarin derivatives in good to high yields. These compounds underwent a cascade sequence of reactions, deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H,11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields.
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