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Merck
CN

H4392

3-羟基-3-甲基谷氨酸

≥95%

别名:

3-羟基-3-甲基戊二酸

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关于此项目

线性分子式:
HOC(CH3)(CH2CO2H)2
化学文摘社编号:
分子量:
162.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-971-1
Beilstein/REAXYS Number:
1769194
MDL number:
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产品名称

3-羟基-3-甲基谷氨酸, ≥95%

assay

≥95%

InChI key

NPOAOTPXWNWTSH-UHFFFAOYSA-N

InChI

1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)

SMILES string

CC(O)(CC(O)=O)CC(O)=O

mp

105-108 °C (lit.)

storage temp.

−20°C

Quality Level

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Application

  • Improvement of the functional value of green soybean (edamame) using germination and tempe fermentation: A comparative metabolomics study.:该研究通过发芽和发酵技术挖掘毛豆更多的功能价值,发现多种代谢产物,包括3-羟基-3-甲基戊二酸。有助了解食品加工和营养生物化学(Iman et al., 2023)。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Beatriz Puisac et al.
Journal of inherited metabolic disease, 33(4), 405-410 (2010-06-10)
3-Hydroxy-3-methylglutaric aciduria is a rare human autosomal recessive disorder caused by deficiency of 3-hydroxy-3-methylglutaryl CoA lyase (HL). This mitochondrial enzyme catalyzes the common final step of leucine degradation and ketogenesis. Acute symptoms include vomiting, seizures and lethargy, accompanied by metabolic
Mohamad Eid Hammadeh et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 47(2), 82-90 (2002-03-20)
The aims of the present study were to (i) determine the presence and concentration of albumin fractions (alpha1, alpha2, beta, gamma), immunoglobulins (IgA, IgG, IgM) and cytokines [interleukin (IL)-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF)] in periovulatory ovarian follicular fluid (FF)
E Pospísilová et al.
Journal of inherited metabolic disease, 26(5), 433-441 (2003-10-02)
Two methods, spectrophotometry and HPLC, were compared in the analyses of 3-hydroxy-3-methylglutaryl-CoA lyase (HL) activity in three unrelated Czech patients with 3-hydroxy-3-methylglutaric (HMG) aciduria and their family members. The HL activities in cultured fibroblasts and/or isolated lymphocytes of probands were
Núria Casals et al.
The Journal of biological chemistry, 278(31), 29016-29023 (2003-05-15)
This study describes three novel homozygous missense mutations (S75R, S201Y, and D204N) in the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase gene, which caused 3-hydroxy-3-methylglutaric aciduria in patients from Germany, England, and Argentina. Expression studies in Escherichia coli show that S75R and S201Y substitutions
Seung Hyun Kim et al.
Bioorganic & medicinal chemistry letters, 20(9), 2824-2827 (2010-04-07)
The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and

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