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Merck
CN

H47003

5-羟基对萘醌

97%

别名:

胡桃酮

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关于此项目

经验公式(希尔记法):
C10H6O3
化学文摘社编号:
分子量:
174.15
Beilstein:
1909764
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案

97%

mp

161-163 °C (lit.)

SMILES字符串

Oc1cccc2C(=O)C=CC(=O)c12

InChI

1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H

InChI key

KQPYUDDGWXQXHS-UHFFFAOYSA-N

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应用

5-羟基-1,4-萘醌(胡桃醌)可作为起始材料用于合成:
  • 杀锥虫药。
  • 他克林-萘醌杂合物,治疗阿茲海默症的潜力药物。
  • 基于胡桃醌的电活性聚合物聚(5-羟基-1,4-萘醌-co-5-羟基-3-硫代醋酸-1,4-萘醌),用于DNA杂交的电化学检测。
  • Ent-nocardione A,天然存在的酪氨酸磷酸酶抑制剂。

胡桃醌还可在狄尔斯–阿尔德反应中作为亲双烯体合成各种C-芳基糖苷。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Nepovimova E, et al.
Journal of medicinal chemistry, 57(20), 8576-8589 (2014)
Application of an Enyne Metathesis/Diels-Alder Cycloaddition Sequence: A New Versatile Approach to the Syntheses of C-Aryl Glycosides and Spiro-C-Aryl Glycosides.
Subrahmanyam AV, et al.
Chemistry?A European Journal , 16(28), 8545-8556 (2010)
2-and 3-substituted 1, 4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from trypanosoma c ruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
Salmon-Chemin L, et al.
Journal of Medicinal Chemistry, 44(4), 548-565 (2001)
Fu-Lan Hsu et al.
Journal of agricultural and food chemistry, 60(12), 3092-3097 (2012-03-03)
Cinnamomum osmophloeum Kaneh is an indigenous tree species in Taiwan. In this study, phytochemical characteristics and antioxidant activities of the essential oils and key constituents from the leaves of two C. osmophloeum clones were investigated. The two trees possess two
G Devagi et al.
Scientific reports, 8(1), 7688-7688 (2018-05-18)
New ruthenium(II) complexes were synthesised and characterized by various spectro analytical techniques. The structure of the complexes 3 and 4 has been confirmed by X-ray crystallography. The complexes were subjected to study their anti-oxidant profile and were exhibited significantly greater

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