H5006
甲基橙皮甙查尔酮
别名:
(E)-1-[4-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-ß-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one
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关于此项目
经验公式（希尔记法）:
C29H36O15
CAS Number:
分子量:
624.59
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
旋光性
[α]20/D −71°, c = 1 in ethanol
质量水平
mp
120 °C (dec.) (lit.)
SMILES字符串
COc1ccc(\C=C\C(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2OC)cc1O
InChI
1S/C29H36O15/c1-12-22(33)24(35)26(37)28(42-12)41-11-20-23(34)25(36)27(38)29(44-20)43-14-9-17(32)21(19(10-14)40-3)15(30)6-4-13-5-7-18(39-2)16(31)8-13/h4-10,12,20,22-29,31-38H,11H2,1-3H3/b6-4+/t12-,20+,22-,23+,24+,25-,26+,27+,28+,29+/m0/s1
InChI key
FDHNLHLOJLLXDH-JIYHLSBYSA-N
应用
Involved in pharmacological studies of:
- The effects on adhesion molecules in vascular endothelium
- Thymidine monophosphate kinase inhibitors as antitubercular agents
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
F A Allaert et al.
International angiology : a journal of the International Union of Angiology, 30(3), 272-277 (2011-05-28)
The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo
N Bouaziz et al.
International angiology : a journal of the International Union of Angiology, 18(4), 306-312 (2000-05-16)
Ruscus aculeatus extract and the flavonoid hesperidin methylchalcone (HMC) are drugs used in the treatment of chronic venous insufficiency. In the present study, we investigated their effects on the activation of endothelial cells by hypoxia, a condition which mimics venous
J J Guex et al.
International angiology : a journal of the International Union of Angiology, 29(6), 525-532 (2010-12-22)
The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients. This study is an observational, single arm, multicentric and prospective trial. Patients suffering
J L Chanal et al.
European journal of drug metabolism and pharmacokinetics, 6(3), 171-177 (1981-01-01)
Hesperidin methylchalcone resorption and excretion were studied in rats, using 14C-labelling. The level of radioactivity in the blood showed a peak 1-2 hours after oral administration of the labelled compound, at a dose of 10 mg/kg body weight. The blood
G R Aguilar Peralta et al.
International angiology : a journal of the International Union of Angiology, 26(4), 378-384 (2007-12-20)
Clinical and capillaroscopic evaluation of an association of Ruscus aculeatus, hesperidin methylchalcone (HMC) and ascorbic acid in chronic venous insufficiency A prospective, multicenter and open clinical study. Chronic venous insufficiency patients were studied using clinical, etiological, anatomical, physiological classification (CEAP)
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