H8520
(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐
≥98%
别名:
(±)-2-二丙基氨基-8-羟基-1,2,3,4-四氢萘, (±)-8-Hydroxy-2-(dipropylamino)tetralin, (±)-8-OH-DPAT
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选择尺寸
关于此项目
经验公式（希尔记法）:
C16H25NO · HBr
化学文摘社编号:
分子量:
328.29
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐, ≥98%
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H
SMILES string
Br[H].CCCN(CCC)C1CCc2cccc(O)c2C1
InChI key
BATPBOZTBNNDLN-UHFFFAOYSA-N
assay
≥98%
Quality Level
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Application
(±)-8-羟基-2-（二丙基氨基）四氢溴酸盐是一种强效的选择性 5-羟色胺 (5HT 1A )-受体激动剂 ，通常作为药理学研究的标准。
Biochem/physiol Actions
选择性 5-HT1 激动剂，对亚型 5-HT1A 受体具有高亲和性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Arylpiperazine agonists of the serotonin 5-HT 1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2.
Stroth N, et al.
Bioorganic & Medicinal Chemistry, 23(15), 4824-4830 (2015)
Laifu Li et al.
eLife, 10 (2021-06-04)
Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition
Improved preparation, chromatographic separation and X-ray crystallographic determination of the absolute configuration of the enantiomers of 8-hydroxy-2-(dipropylamino) tetralin (8-OH DPAT).
Karlsson A, et al.
Acta Chemica Scandinavica, 42, 231-236 (1988)
8-Hydroxy-2-(dipropylamino) tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
Arvidsson L E, et al.
Journal of Medicinal Chemistry, 24(8), 921-923 (1981)
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.
D N Middlemiss et al.
European journal of pharmacology, 90(1), 151-153 (1983-05-20)
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