I17451
异烟酰胺
ReagentPlus®, 99%
别名:
吡啶-4-甲酰胺
产品线
ReagentPlus®
方案
99%
mp
155-157 °C (lit.)
SMILES字符串
NC(=O)c1ccncc1
InChI
1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)
InChI key
VFQXVTODMYMSMJ-UHFFFAOYSA-N
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应用
异烟酰胺（吡啶-4-甲酰胺）可作为合成以下物质的杂环结构单元：
它还可用作共晶试剂（co-former）,与活性药物成分（API）一起制备共晶体。
- 潜在抗结核剂4-氧代-1,3-噻嗪烷-3-基异烟酰胺衍生物。
- 通过合成氨基磷酸酯配体制备的用于各种生物活性研究的异烟酰胺有机锡 (IV) 复合物。
- 2-(羟基亚氨基)-N-(吡啶-3-基)乙酰胺的双吡啶鎓异烟酰胺衍生物，其是一种强效活化剂沙林
它还可用作共晶试剂（co-former）,与活性药物成分（API）一起制备共晶体。
法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
New organotin (IV) complexes of nicotinamide, isonicotinamide and some of their novel phosphoric triamide derivatives: Syntheses, spectroscopic study and crystal structures
Gholivand K, et al.
Journal of Organometallic Chemistry, 695(9), 1383-1391 (2010)
QSAR, docking studies of 1, 3-thiazinan-3-yl isonicotinamide derivatives for antitubercular activity
Chitre TS, et al.
Computational Biology and Chemistry, 68, 211-218 (2017)
Joseph A Baur
Biochimica et biophysica acta, 1804(8), 1626-1634 (2009-11-10)
SIRT1 is the closest mammalian homologue of enzymes that extend life in lower organisms. Its role in mammals is incompletely understood, but includes modulation of at least 34 distinct targets through its nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase activity. Recent experiments
Jianqi Yang et al.
The Journal of biological chemistry, 284(40), 27042-27053 (2009-08-05)
The SIRT1 activators isonicotinamide (IsoNAM), resveratrol, fisetin, and butein repressed transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). An evolutionarily conserved binding site for hepatic nuclear factor (HNF) 4alpha (-272/-252) was identified, which was required
Srinu Tothadi et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 370(1969), 2900-2915 (2012-05-23)
The idea of a structural landscape is based on the fact that a large number of crystal structures can be associated with a particular organic molecule. Taken together, all these structures constitute the landscape. The landscape includes polymorphs, pseudopolymorphs and
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