K2755
2-酮基-3-脱氧辛烷 铵盐
≥97%
别名:
3-脱氧辛酮糖酸, KDO
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关于此项目
线性分子式:
C8H14O8 · NH3
化学文摘社编号:
分子量:
255.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
2-酮基-3-脱氧辛烷 铵盐, ≥97%
InChI
1S/C8H14O8.H3N/c9-2-4(11)6-5(12)3(10)1-8(15,16-6)7(13)14;/h3-6,9-12,15H,1-2H2,(H,13,14);1H3
SMILES string
N.OCC(O)C1OC(O)(CC(O)C1O)C(O)=O
InChI key
UDJBBKGYARWWNJ-UHFFFAOYSA-N
assay
≥97%
form
powder
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
KDO 是一种唾液酸，是细菌脂多糖的成分以及抗生素研发的可用靶标。
Application
- KDO类似物的合成：研究3-脱氧-D-甘露-辛酮糖酸(KDO)类似物的合成，包括2-酮基-3-脱氧辛酮酸铵盐。这些类似物是CMP-KDO合成酶的潜在抑制剂，对于开发治疗细菌感染的新药十分重要，有助于加强对细菌脂多糖合成的了解(Luthman et al., 1987)。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Cadi Davies et al.
Frontiers in cellular and infection microbiology, 9, 177-177 (2019-06-14)
Campylobacter jejuni outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As C. jejuni lacks the classical virulence-associated secretion systems of other enteric pathogens that deliver effectors directly into target cells, OMVs
Laura Cipolla et al.
Current drug discovery technologies, 6(1), 19-33 (2009-03-12)
Despite important advances made in the last century, infectious diseases caused by pathogenic microrganisms are still a major threat to human health. This is worsened by the occurrence of new forms of bacterial resistance against antibiotics, that are the main
Karla Diaz-Ordaz et al.
BMC medical research methodology, 13, 127-127 (2013-10-24)
Previous reviews of cluster randomised trials have been critical of the quality of the trials reviewed, but none has explored determinants of the quality of these trials in a specific field over an extended period of time. Recent work suggests
Aloka B Bandara et al.
PloS one, 6(4), e19003-e19003 (2011-05-06)
Francisella tularensis is a category-A select agent and is responsible for tularemia in humans and animals. The surface components of F. tularensis that contribute to virulence are not well characterized. An electron-dense capsule has been postulated to be present around
Blanka Bucsella et al.
Analytical methods : advancing methods and applications, 12(38), 4621-4634 (2020-09-15)
The paper presents a novel instrumental analytical endotoxin quantification assay. It uses common analytical laboratory equipment (HPLC-FLD) and allows quantifying endotoxins (ETs) in different matrices from about 109 EU per mL down to about 40 EU per mL (RSE based).
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