M14935
5-甲氧基-3-吲哚乙酸
98%
别名:
2-(5-Methoxy-3-indolyl)acetic acid
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关于此项目
经验公式（希尔记法）:
C11H11NO3
化学文摘社编号:
分子量:
205.21
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
222-438-3
Beilstein/REAXYS Number:
187161
MDL number:
产品名称
5-甲氧基-3-吲哚乙酸, 98%
InChI key
COCNDHOPIHDTHK-UHFFFAOYSA-N
InChI
1S/C11H11NO3/c1-15-8-2-3-10-9(5-8)7(6-12-10)4-11(13)14/h2-3,5-6,12H,4H2,1H3,(H,13,14)
SMILES string
COc1ccc2[nH]cc(CC(O)=O)c2c1
assay
98%
mp
145-148 °C (dec.) (lit.)
Quality Level
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Application
- Reactant for preparation of aryloxybenzothiazoles as inhibitors of NO production
- Reactant for preparation of transcription inhibitors of novel Gli1 as antitumor agents
- Reactant for preparation of indole derivatives as NR2B/NMDA receptor antagonists
- Reactant for preparation of indolyl esters and amides related to indomethacin as selective COX-2 inhibitors
- Reactant for preparation of quinoline salicylic acid series of P-selectin antagonists
- Reactant for preparation of prostaglandin D2 receptor antagonists
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
L A Bondarenko et al.
Biulleten' eksperimental'noi biologii i meditsiny, 110(8), 150-151 (1990-08-01)
5-day morning injections to pubertal male rats of polypeptide epithalamin preparation obtained from cattle epiphysis, in dose of 0.25 mg/100 g body mass induced the increase of serotonin epiphyseal concentration night peak, N-acetylserotonin and melatonin and didn't produce any essential
Satoshi Furukawa et al.
The Journal of toxicological sciences, 30(3), 165-174 (2005-09-06)
Indole-3-acetic acid (IAA), a natural auxin, induces microencephaly in rats exposed to IAA during gestation days (Days) 12-14, corresponding to the early stage of cerebral cortex development. The purpose of this study was to examine the effects of 5 IAA
P Li et al.
Biochemical and biophysical research communications, 239(1), 353-356 (1997-11-05)
Endogenous 5-methoxytryptamine (5MT) and its biosynthetic oxidation product, 5-methoxyindole-3-acetic acid (5MIAA), were successfully identified and measured in the retina of the rat and quail by gas chromatography/electron-capture negative ion chemical ionization mass spectrometry (GC/EC-NICI-MS). In the rat retina, diurnal rhythms
V E Ooi et al.
Journal of pineal research, 7(4), 315-324 (1989-01-01)
The effects of late-afternoon injections of melatonin (MEL), 5-methoxytryptamine (MTN), 5-methoxytryptophol (MTOL), and 5-methoxyindole-3-acetic acid (MIAA) on testicular and seminal vesicular histology in the golden hamster were examined. MEL, MTN, and MTOL injections caused a reduction in the diameters of
A A Levchuk et al.
Biulleten' eksperimental'noi biologii i meditsiny, 104(7), 77-79 (1987-07-01)
A comparative study of the effect produced by endogenous carcinogens (p-hydroxyphenyllactic and 5-methoxyindole-3-acetic acids) and their non-cancerogenic analogues on lipid peroxidation in vitro and in vivo was performed. It has been found that cancerogenic tyrosine and serotonin metabolites, unlike their
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