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Merck
CN

M2780

Sigma-Aldrich

N 6 -甲基腺苷 5′-单磷酸 钠盐

≥97% (HPLC)

别名:

6-Me-5′-AMP, N-甲基-5′-腺苷酸二钠盐

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关于此项目

线性分子式:
C11H15N5O7PNa
CAS Number:
分子量:
383.23
UNSPSC代码:
41106305
PubChem化学物质编号:
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质量水平

方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

[Na].CNc1ncnc2n(cnc12)C3OC(COP(O)(O)=O)C(O)C3O

InChI

1S/C11H16N5O7P.2Na/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(23-11)2-22-24(19,20)21;;/h3-5,7-8,11,17-18H,2H2,1H3,(H,12,13,14)(H2,19,20,21);;/q;2*+1/p-2/t5-,7-,8-,11-;;/m1../s1

InChI key

HFOKUKRAZPHTHH-LYYWGVPGSA-L

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应用

N6-甲基腺苷 5′-单磷酸钠盐可以用于N6-甲基腺苷(m6A) 核糖核蛋白酶免疫沉淀反应。m6A在近几年获得了许多关注,因为m6A mRNA修饰在mRNA稳定和转译效率中起到作用。

生化/生理作用

一种糖原磷酸化酶 b 活化剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

M Morange et al.
European journal of biochemistry, 65(2), 553-563 (1976-06-01)
A series of AMP analogs has been selected in order to better understand the structural requirements (a) for the efficient binding of the activator molecule at the correct site on phosphorylase b from rabbit skeletal muscle and (b) for the
N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.
Fry N J, et al.
RNA, 23(9), 1444-1455 (2017)
N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Wang X, et al.
Cell, 161(6), 1388-1399 (2015)
Kosuke Taniguchi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 494-512 (2020-01-10)
Intracellular mRNA levels are not always proportional to their respective protein levels, especially in the placenta. This discrepancy may be attributed to various factors including post-transcriptional regulation, such as mRNA methylation (N6-methyladenosine: m6A). Here, we conducted a comprehensive m6A analysis
Fengchao Lang et al.
PLoS pathogens, 15(6), e1007796-e1007796 (2019-06-22)
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV

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