Merck
CN
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文件

N1280

Sigma-Aldrich

去甲氯米帕明 盐酸盐

≥98% (TLC), powder

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别名:
N-去甲氯丙咪嗪
经验公式（希尔记法）:
C18H21ClN2 · HCl
CAS号:
303-48-0
分子量:
337.29
MDL编号:
MFCD00792880
PubChem化学物质编号:
57654438
NACRES:
NA.22

质量水平

200

检测方案

≥98% (TLC)

形式

powder

颜色

white to yellow

SMILES字符串

Cl.CNCCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C18H21ClN2.ClH/c1-20-11-4-12-21-17-6-3-2-5-14(17)7-8-15-9-10-16(19)13-18(15)21;/h2-3,5-6,9-10,13,20H,4,7-8,11-12H2,1H3;1H

InChI key

KMDDAZOLOSKTKZ-UHFFFAOYSA-N

相关类别

生化/生理作用

三环抗抑郁剂；氯米帕明的活性代谢物，优先阻断去甲肾上腺素转运体。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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K Fujita et al.
European journal of pharmacology, 204(3), 227-233 (1991-11-12)
When rats received a single i.p. injection of clomipramine (20 mg/kg), clomipramine and desmethylclomipramine were rapidly distributed into the brain and their concentrations were markedly higher in the brain than in the serum, while the concentration of the metabolite in
S Härtter et al.
Psychopharmacology, 117(2), 149-153 (1995-01-01)
The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in
R de la Torre et al.
Therapeutic drug monitoring, 20(3), 340-346 (1998-06-19)
An analytical method for the simultaneous determination of amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, and desmethylclomipramine in human plasma using promazine as internal standard is described. The method is based on a solid-phase extraction procedure using the Bond-Elut TCA columns followed
M Gex-Fabry et al.
Therapeutic drug monitoring, 22(6), 701-711 (2000-12-29)
Because metabolites play a major role in the clinical response to clomipramine, the objective of the current study was to develop a population model and evaluate its performance to describe the pharmacokinetic profiles of clomipramine (C) and its active metabolites
K Aitchison et al.
Journal of psychopharmacology (Oxford, England), 24(8), 1261-1268 (2009-06-26)
The tricyclic antidepressant (TCA) clomipramine has been widely used in psychiatry for over 40 years. More recently, its therapeutic potential as an antineoplastic drug has been identified. However, there are no prior data on regional distribution in the brain of
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