质量水平
方案
98%
表单
powder
mp
140-142 °C (lit.)
SMILES字符串
[O-][N+](=O)c1ccc2[nH]ccc2c1
InChI
1S/C8H6N2O2/c11-10(12)7-1-2-8-6(5-7)3-4-9-8/h1-5,9H
InChI key
OZFPSOBLQZPIAV-UHFFFAOYSA-N
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应用
作为以下制备反应的反应物：
- 具有药物活性的 2-氧代-1-吡咯烷类似物
- 色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚类化合物可作为潜在的抗癌免疫调节剂
- 蛋白激酶抑制剂和抗增殖剂
- 代谢型谷氨酸受体4（mGlu4）的正变构调节剂。
- 抗真菌剂
- 大麻素1型受体（CB1）拮抗剂
- 潜在抗癌剂
- 潜在的抗血管药
- 选择性抗白血病药
- 抗人类免疫缺陷病毒亚型1（HIV-1）的药物
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Wengen Ouyang et al.
Journal of chemical theory and computation, 16(1), 666-676 (2019-12-10)
The importance of many-body dispersion effects in layered materials subjected to high external loads is evaluated. State-of-the-art many-body dispersion density functional theory calculations performed for graphite, hexagonal boron nitride, and their heterostructures were used to fit the parameters of a
D Loakes et al.
Nucleic acids research, 22(20), 4039-4043 (1994-10-11)
4-, 5- and 6-Nitroindole have been investigated and compared with 3-nitropyrrole as universal bases in oligodeoxynucleotides. Of these the 5-nitroindole derivative was found to be superior giving higher duplex stability, and behaving indiscriminately towards each of the four natural bases
Caroline Crey-Desbiolles et al.
Nucleic acids research, 33(5), 1532-1543 (2005-03-16)
Universal DNA base analogs having photocleavable properties would be of great interest for development of new nucleic acid fragmentation tools. The photocleavable 7-nitroindole 2'-deoxyribonucleoside d(7-Ni) was previously shown to furnish a highly efficient approach to photochemically trigger DNA backbone cleavage
Junbin Zhang et al.
Chembiochem : a European journal of chemical biology, 13(13), 1940-1945 (2012-08-14)
During the formation of RNA-induced silencing complex (RISC), the passenger and guide strand of an siRNA duplex separate from each other to generate an active RISC complex. Accumulating evidence shows that an siRNA passenger strand can also assemble into a
S Ball et al.
Nucleic acids research, 26(22), 5225-5227 (1998-11-04)
Studies have been carried out on the use of octamer oligonucleotides tailed with different base analogues as primers in cycle sequencing reactions. 5-Nitroindole tails improved the performance as primers of a number of octamers. A tail length of three or
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