N3386
D -(+)-新蝶呤
≥97.5% (sum of enantiomers, HPLC)
别名:
D-赤型新蝶呤
质量水平
方案
≥97.5% (sum of enantiomers, HPLC)
表单
powder
储存温度
2-8°C
SMILES字符串
Nc1nc(O)c2nc(cnc2n1)[C@H](O)[C@H](O)CO
InChI
1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
InChI key
BMQYVXCPAOLZOK-XINAWCOVSA-N
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一般描述
D-(+)-新蝶呤是一种蝶啶衍生物,天然存在于盘基网柄菌中。 其在癌症患者的尿液中被发现大量存在。
应用
在评估乳腺癌细胞中NADPH氧化酶产生活性氧(ROS)的能力时,D-(+)-新蝶呤可被用作NADPH氧化酶的抑制剂。[NADPH =烟酰胺腺嘌呤二核苷酸磷酸]
生化/生理作用
喋呤辅因子;BH4(四氢生物蝶呤)的前体。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Dictyopterin, 6-(d-threo-1,2-dihydroxypropyl)-pterin, a new natural isomer of L-biopterin.
Klein R, et al.
European Journal of Biochemistry, 187(3), 665-669 (1990)
Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection.
Han F, et al.
Analytical Chemistry, 71(7), 1265-1269 (1999)
R Caruso et al.
Clinical biochemistry, 46(1-2), 94-98 (2012-10-30)
Neopterin, a marker of inflammation and monocyte activation, is found increased in patients with heart failure (HF). This study investigates whether neopterin levels correlate with left ventricular (LV) remodeling and brain natriuretic peptide (BNP), a marker of cardiac stress, in
Petra Holečková et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(2), 77-84 (2012-10-16)
High serum or urinary neopterin concentrations are associated with poor prognosis in patients with tumors of different primary locations, but reports on neopterin in patients with head and neck carcinoma are relatively less numerous. It has been established that decreased
Nisreen Husain et al.
Journal of clinical gastroenterology, 47(3), 246-251 (2012-12-28)
Neopterin, a pyrazino-[2,3-d]-pyrimidine compound, is a metabolite of cyclic guanosine monophosphate that is released by activated T lymphocytes and macrophages after induction by γ interferon. We sought to determine whether neopterin concentration in stool, serum, or urine is a useful
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