N3633
β-萘黄酮
≥98%
别名:
5,6-苯并黄酮, BNF
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关于此项目
经验公式（希尔记法）:
C19H12O2
化学文摘社编号:
分子量:
272.30
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
227-958-4
Beilstein/REAXYS Number:
18991
MDL number:
产品名称
β-萘黄酮, ≥98%
InChI key
OUGIDAPQYNCXRA-UHFFFAOYSA-N
InChI
1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
SMILES string
O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
assay
≥98%
color
off-white to yellow
mp
164-166 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Gabra2(29706)
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Application
β-萘黄酮已用于：
- 作为芳烃受体激动剂，阐明其对转基因细胞色素 P450 1A1（cyp1a）报告基因的斑马鱼胚胎中 Cyp1A1 表达的影响
- 作为 AhR 激动剂，处理原代正常人表皮角质形成细胞（NHEKs），通过蛋白质印迹法研究芳香烃受体（AhR）激活
- 确定其对肌营养不良蛋白（Dp）71 表达的影响
- 刺激 Cre 重组酶的表达，并删除侧翼为 loxP 序列的等位基因
Biochem/physiol Actions
β-萘黄酮是人体中芳烃受体（AhR）的外源配体。它是 I 期解毒酶（CYP）和 II 期酶（UDP-GTs）和 NAD(P)H 依赖性醌氧还原酶-1（NQO1）的诱导物。它还诱导细胞色素 P450（Cyp1a）的表达。BNF 通过改变转录因子的结合来抑制 Duchenne 肌营养不良基因（肌营养不良蛋白（Dp）71） 的表达。
General description
β-萘黄酮是一种多环芳烃。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Cyp1a reporter zebrafish reveals target tissues for dioxin
Kim KH, et al.
Aquatic Toxicology (Amsterdam, Netherlands), 134, 57-65 (2013)
Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice
Tang X, et al.
Scientific data, 3(4), 160008-160008 (2016)
beta-naphthoflavone interferes with cyp1c1, cox2 and IL-8 gene transcription and leukotriene B4 secretion in Atlantic cod (Gadus morhua) head kidney cells during inflammation
Holen E and Olsvik P
Fish & Shellfish Immunology, 54(1), 128-134 (2016)
Ryeo-Ok Kim et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 157(2), 172-182 (2012-11-28)
CYP1A is involved in the metabolism of diverse chemicals, including polycyclic aromatic hydrocarbons and alkylated-PAHs, as a first line of detoxification mechanism. First, we identified and characterized the CYP1A gene from the marine medaka, Oryzias melastigma. O. melastigma CYP1A (Om-CYP1A)
Luísa K Pilz et al.
Scientific reports, 8(1), 11402-11402 (2018-08-01)
Despite emerging evidence that disruption in circadian rhythms may contribute to the pathophysiology of psychiatric disorders, there is a significant knowledge gap on the rhythmicity of psychological symptoms. Here, we aimed at investigating the rhythmicity of mood symptoms in individuals
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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