N3633
β-萘黄酮
≥98%
别名:
5,6-苯并黄酮, BNF
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关于此项目
经验公式（希尔记法）:
C19H12O2
化学文摘社编号:
分子量:
272.30
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
227-958-4
Beilstein/REAXYS Number:
18991
MDL number:
Assay:
≥98%
Quality Level
assay
≥98%
color
off-white to yellow
mp
164-166 °C (lit.)
storage temp.
2-8°C
SMILES string
O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
InChI
1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
InChI key
OUGIDAPQYNCXRA-UHFFFAOYSA-N
Gene Information
rat ... Gabra2(29706)
General description
β-萘黄酮是一种多环芳烃。
Application
β-萘黄酮已用于：
- 作为芳烃受体激动剂，阐明其对转基因细胞色素 P450 1A1（cyp1a）报告基因的斑马鱼胚胎中 Cyp1A1 表达的影响
- 作为 AhR 激动剂，处理原代正常人表皮角质形成细胞（NHEKs），通过蛋白质印迹法研究芳香烃受体（AhR）激活
- 确定其对肌营养不良蛋白（Dp）71 表达的影响
- 刺激 Cre 重组酶的表达，并删除侧翼为 loxP 序列的等位基因
Biochem/physiol Actions
β-萘黄酮是人体中芳烃受体（AhR）的外源配体。它是 I 期解毒酶（CYP）和 II 期酶（UDP-GTs）和 NAD(P)H 依赖性醌氧还原酶-1（NQO1）的诱导物。它还诱导细胞色素 P450（Cyp1a）的表达。BNF 通过改变转录因子的结合来抑制 Duchenne 肌营养不良基因（肌营养不良蛋白（Dp）71） 的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
The polyaromatic hydrocarbon beta-naphthoflavone alters binding of YY1, Sp1, and Sp3 transcription factors to the Dp71 promoter in hepatic cells
Becerril-Esquivel C, et al.
Molecular Medicine Reports, 17(4), 6150-6155 (2018)
Induction of a chloracne phenotype in an epidermal equivalent model by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down
Forrester AR, et al.
Journal of Dermatological Science, 73(1), 10-22 (2014)
Preethi Korangath et al.
Science advances, 6(13), eaay1601-eaay1601 (2020-04-02)
The factors that influence nanoparticle fate in vivo following systemic delivery remain an area of intense interest. Of particular interest is whether labeling with a cancer-specific antibody ligand ("active targeting") is superior to its unlabeled counterpart ("passive targeting"). Using models
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N3633-5G | 04061834116233 |
| N3633-1G | 04061834116226 |