O2256
奥索拉明 柠檬酸盐
别名:
5-(2-[二乙基氨基]乙基)-3-苯基-1,2,4-噁二唑
质量水平
储存温度
2-8°C
SMILES字符串
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)CCc1nc(no1)-c2ccccc2
InChI
1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI key
RBZIGQJSMCOHSS-UHFFFAOYSA-N
应用
Molecule involved in pharmacological studies including:
- Antiinflammatory agents
- Drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- Effect on warfarin anticoagulant properties
Effect of oxolamine on cough sensitivity in COPD patients.
B B Ceyhan et al.
Respiratory medicine, 96(1), 61-63 (2002-02-28)
J McEwen et al.
The Medical journal of Australia, 150(8), 449-450 (1989-04-17)
Twenty reports in Australia, Belgium and The Netherlands have implicated oxolamine-citrate cough-mixtures as a cause of hallucinations in children of less than 10 years of age. Fever is not thought to be a likely alternative explanation. Similar reactions in older
Xuan Zhu et al.
Biopharmaceutics & drug disposition, 28(3), 125-133 (2007-02-14)
The possible reason for the significantly greater AUC of oral warfarin with oral oxolamine in male Sprague-Dawley rats was evaluated. After oral administration of warfarin at a dose of 2 mg/kg to male rats with oxolamine at doses of 10
[Therapeutic action of oxolamine in acute tracheo-bronchitis].
G Gunella et al.
La Clinica terapeutica, 100(5), 485-492 (1982-03-15)
L Kirilmaz et al.
Journal of microencapsulation, 9(2), 167-172 (1992-04-01)
One of the principal uses of microencapsulation for pharmaceuticals has been the preparation of sustained-release dosage forms which have been usually presented in the form of a suspension or gel. However, a non-disintegrating tablet would be a better formulation to
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