P0256
吡啶硫胺 氢溴酸盐
~95%, crystalline
别名:
1-([4-氨基-2-甲基]-5-嘧啶基甲基)-2-甲基-3-(β-羟乙基)溴化吡啶鎓, 新吡啶硫胺
方案
~95%
质量水平
表单
crystalline
颜色
off-white to yellow
储存温度
2-8°C
SMILES字符串
Br.[Br-].Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1
InChI
1S/C14H19N4O.2BrH/c1-10-12(5-7-19)4-3-6-18(10)9-13-8-16-11(2)17-14(13)15;;/h3-4,6,8,19H,5,7,9H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChI key
DMVBWVASDWGFNH-UHFFFAOYSA-M
一般描述
吡啶硫胺氢溴酸盐是一种杂环化合物合成砌块，由于能够模拟硫胺素缺乏症且可能用于开发具有实用药理特性的新化合物，因而成为重要的有机合成和药物化学工具。
应用
吡啶硫胺氢溴酸盐可用作合成焦磷酸吡硫胺的前体。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Jessica J Roland et al.
Neurobiology of learning and memory, 87(1), 123-132 (2006-09-19)
A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate the dynamic role of hippocampal and striatal acetylcholine (ACh) efflux across acquisition of a nonmatching-to-position (NMTP) T-maze task. Changes in ACh efflux were measured in rats
Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine
Sudarsan, et al.
Chemistry & Biology, 12, 1325-1335 (2005)
Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen
Tiwana, et al.
Oncotarget, 6, 5978-5978 (2015)
Steven Anzalone et al.
The European journal of neuroscience, 32(5), 847-858 (2010-08-24)
Although the key neuropathology associated with diencephalic amnesia is lesions to the thalamus and/or mammillary bodies, functional deactivation of the hippocampus and associated cortical regions also appear to contribute to the memory dysfunction. For example, there is loss of forebrain
Darren Navarro et al.
Journal of neurochemistry, 106(2), 603-612 (2008-04-16)
Thiamine deficiency provides an effective model of selective neuronal cell death. (1)H and (13)C-NMR was used to investigate the effects of thiamine deficiency on the synthesis of amino acids derived from [1-(13)C]glucose in vulnerable (medial thalamus; MT) compared to non-vulnerable
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