P2066
聚（D,L-丙交酯-co-乙交酯）
lactide:glycolide 65:35, Mw 40,000-75,000
别名:
Lactel® B6001-1, PLGA
表单
pellets
质量水平
投料比
lactide:glycolide 65:35
分子量
Mw 40,000-75,000
储存温度
−20°C
SMILES字符串
OCC(O)=O.CC(O)C(O)=O
InChI
1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
InChI key
XBBVURRQGJPTHH-UHFFFAOYSA-N
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应用
- 吸入巨噬细胞凋亡体-工程微粒可构建促退行性微环境以对抗小鼠缺氧性肺损伤。：这项研究展示了利用聚（D,L-乳酸-共-乙醇酸）（PLGA）工程微粒在缺氧条件下促进肺组织再生的方法，凸显了其在开发先进的呼吸道损伤治疗策略方面的潜力（Liu et al., 2024）。
- 工程纳米颗粒促进了AAV向量对心脏的滋养。：该研究探讨了PLGA纳米颗粒在提高AAV载体对心脏组织的靶向效率方面的作用，展示了其在基因治疗和心血管疾病治疗中的应用（Switala et al., 2024）。
- 用于预防口腔表面生物膜的载药粘合微粒。：这篇文章报道了为防止口腔表面生物膜形成而设计的药物负载 PLGA 微颗粒的开发情况，展示了这种聚合物在牙科应用和生物膜相关感染中的实用性（Oh et al., 2024）。
- 含有VEGF-A-转染Schwann细胞的双层导管通过血管生成促进周围神经再生。：基于PLGA的双层导管可通过增强血管生成来支持神经再生，这表明了它在神经再生医学和周围神经损伤治疗中的重要性（Huang et al., 2024）。
- 在模拟黑色素瘤和皮肤鳞状细胞癌的三维人体皮肤模型上应用负载多柔比星的PLGA纳米粒子，靶向肿瘤细胞和癌症相关成纤维细胞。：该研究强调了聚乳酸乙二醇（PLGA）纳米颗粒在向肿瘤细胞和周围支持基质输送化疗药物方面的双重靶向能力，突出了其在晚期癌症疗法中的作用（He et al., 2024）。
特点和优势
控释生物活性剂、缝线和可生物吸收植入器件。
外形
具有生物相容性且可生物降解的聚合物。
法律信息
Lactel is a registered trademark of Evonik Corp
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Engineering Cell Adhesion and Orientation via Ultrafast Laser Fabricated Microstructured Substrates.
Eleftheria Babaliari et al.
International journal of molecular sciences, 19(7) (2018-07-18)
Cell responses depend on the stimuli received by the surrounding extracellular environment, which provides the cues required for adhesion, orientation, proliferation, and differentiation at the micro and the nano scales. In this study, discontinuous microcones on silicon (Si) and continuous
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
商品
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
实验方案
Preparation for biodegradable nanoparticles and their use in transfection protocols .
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