P57204
哒嗪
98%
别名:
1,2-二氮杂苯, 1,2-噻嗪, 邻噻嗪
方案
98%
折射率
n20/D 1.524 (lit.)
沸点
208 °C (lit.)
mp
−8 °C (lit.)
密度
1.103 g/mL at 25 °C (lit.)
SMILES字符串
c1ccnnc1
InChI
1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H
InChI key
PBMFSQRYOILNGV-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
一般描述
哒嗪是一种单碱式1,2-二嗪化合物，通常可通过1,4-二羰基与肼反应进行制备。哒嗪环存在于如克雷达嗪、吡哆醇等多种除草剂，以及如头孢唑仑、奥拉帕利、他拉唑帕利和卡达拉嗪等多种药物中。
应用
哒嗪可用于：
- 作为构建单元，用于合成可作为GSK-3抑制剂的N-苯基-4-吡唑并[1,5-b]哒嗪-3-基-嘧啶-2-胺衍生物。
- 作为合成具有重要药用价值的吡咯并[1,2-b]哒嗪衍生物的起始材料。
- 在酸性条件下制备可作为钢铁缓蚀剂的1-（6-乙氧基-6-氧代己基）哒嗪-1-溴化铵和1-（2-溴乙酰基）哒嗪溴化铵离子液体。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
185.0 °F - closed cup
闪点(°C)
85 °C - closed cup
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Ying Zhao et al.
ChemMedChem, 7(5), 861-870 (2012-03-15)
Dihydropteroate synthase (DHPS) is the validated drug target for sulfonamide antimicrobial therapy. However, due to widespread drug resistance and poor tolerance, the use of sulfonamide antibiotics is now limited. The pterin binding pocket in DHPS is highly conserved and is
Pyridazinium-based ionic liquids as novel and green corrosion inhibitors of carbon steel in acid medium: electrochemical and molecular dynamics simulation studies
El-Hajjaji F, et al.
Journal of Molecular Liquids, 249(1), 997-1008 (2018)
Dorina Mantu et al.
European journal of medicinal chemistry, 45(11), 5164-5168 (2010-09-04)
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds
Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives
Popovici L, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 230-243 (2019)
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules
He Z-X, et al.
European Journal of Medicinal Chemistry, 112946-112946 (2020)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持