相关类别
一般描述
This set includes 4 representative partial PROTACs, each provided at 5 micromole quantity.
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应用
The QuicTPD Acid Optimization set is designed to facilitate high throughput synthesis optimization for researchers working with PROTACs.
特点和优势
Two of these PROTACs are tailored to target the CRBN E3 ligase, while the other two are directed towards VHL, incorporating both hydrophobic and hydrophilic linkers. By utilizing this optimization set, customers can explore a variety of reaction conditions—up to 24 or more—before proceeding to the complete screening set. This exploration includes testing different coupling reagents, solvents, and bases, allowing for a comprehensive assessment of the synthesis parameters that influence the efficiency and yield of the desired products.
其他说明
QuicTPD Amine Screening Set
法律信息
QuicTPD is a trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险分类
Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2
靶器官
Blood
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
Charles E Hendrick et al.
ACS medicinal chemistry letters, 13(7), 1182-1190 (2022-07-22)
A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects. A large number of linker analogs-with varying length, polarity, and rigidity-were rapidly prepared and characterized in
Ke-Nian Yan et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(26), e2400594-e2400594 (2024-05-01)
Proteolysis targeting chimeras (PROTACs) have emerged as a promising strategy for drug discovery and exploring protein functions, offering a revolutionary therapeutic modality. Currently, the predominant approach to PROTACs discovery mainly relies on an empirical design-synthesis-evaluation process involving numerous cycles of
Rebecca Stevens et al.
Journal of medicinal chemistry, 66(22), 15437-15452 (2023-11-07)
Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules that co-opt the cell's natural proteasomal degradation mechanisms to degrade undesired proteins. A challenge associated with PROTACs is the time and resource-intensive optimization; thus, the development of high-throughput platforms for their synthesis and
Zefeng Wang et al.
Nature communications, 14(1), 8437-8437 (2023-12-20)
Thalidomide and its analogs are molecular glues (MGs) that lead to targeted ubiquitination and degradation of key cancer proteins via the cereblon (CRBN) E3 ligase. Here, we develop a direct-to-biology (D2B) approach for accelerated discovery of MGs. In this platform
商品
Discover QuicTPD™ Acid/Amine Screening Sets for rapid, high-throughput PROTAC® synthesis, streamlining targeted protein degradation research.
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