QBD10918
m-dPEG®48-amine
>95% (HPLC)
别名:
m-PEG48-amine, mPEG-amine, mPEG2000-amine, mPEG48-NH2
SMILES string
NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
InChI key
NCWDZRVHWBSGGG-UHFFFAOYSA-N
assay
>95% (HPLC)
form
solid or viscous liquid
reaction suitability
reaction type: Pegylations
polymer architecture
shape: linear
functionality: monofunctional
shipped in
ambient
storage temp.
−20°C
Features and Benefits
m-dPEG48-amine is a methyl-terminated PEG amine compound. The PEG is a water-soluble, single molecular weight PEG product with a discrete chain length (dPEG). This dPEG linker is 146 atoms (173.1 Å) long, a monodisperse equivalent of a PEG2000. Carboxylic acids and their active esters react with the amino terminus to form amide bonds. Also, the amino terminus reacts with aldehydes and ketones, forming Schiff bonds, which are reducible to secondary amines. Uses for m-dPEG48-amine include modification of acid-functionalized surfaces and free carboxylic acid groups on biomolecules.
Legal Information
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
George Badescu et al.
Bioconjugate chemistry, 25(3), 460-469 (2014-02-12)
Many clinically used protein therapeutics are modified to increase their efficacy. Example modifications include the conjugation of cytotoxic drugs to monoclonal antibodies or poly(ethylene glycol) (PEG) to proteins and peptides. Monothiol-specific conjugation can be efficient and is often accomplished using
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