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经验公式(希尔记法):
C6H8N2O2 · HCl
化学文摘社编号:
分子量:
176.60
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
285-687-7
MDL number:
产品名称
加波沙朵 盐酸盐, solid, ≥98% (HPLC)
InChI key
ZDZDSZQYRBZPNN-UHFFFAOYSA-N
InChI
1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
SMILES string
Cl[H].Oc1noc2CNCCc12
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
ethanol: 0.91 mg/mL
H2O: 20 mg/mL
Quality Level
Gene Information
Application
盐酸加波沙朵已被用于细胞迁移和侵袭测定以评估肝癌细胞的迁移。
Biochem/physiol Actions
GABAA 受体激动剂。
Disclaimer
光敏
General description
加波沙朵,也称为4,5,6,7-四氢异恶唑并(5,4-c)吡啶-3-醇(THIP),是一种GABA位点激动剂。它对突触外高亲和力GABAA受体的δ 亚基具有很强的亲和力。 加波沙朵最初被用于治疗精神分裂症、癫痫、原发性失眠症 和亨廷顿病。它很容易穿过血脑屏障,并迅速被人体吸收。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M Lancel
Sleep, 22(1), 33-42 (1999-02-16)
This paper reviews the sleep effects of systemically administered agonistic modulators of GABAA receptors, including barbiturates, benzodiazepines, zolpidem, zopiclone and neuroactive steroids, and the selective GABAA agonists muscimol and THIP. To assess the involvement of GABAA receptors in the physiologic
GABA and Sleep: Molecular, Functional and Clinical Aspects (2010)
Vanessa M Hill et al.
PLoS biology, 16(7), e2005206-e2005206 (2018-07-13)
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into
Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor
Chen ZA, et al.
Cancer Biology & Medicine, 9(2), 90-90 (2012)
GABA Site Agonist Gaboxadol Induces Addiction-Predicting Persistent Changes in Ventral Tegmental Area Dopamine Neurons But Is Not Rewarding in Mice or Baboons
Vashchinkina E, et al.
The Journal of Neuroscience, 32(15), 5310-5320 (2012)
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