T111
8-(二乙氨基)辛基-3,4,5-三甲氧基苯甲酸酯 盐酸盐
≥98%
别名:
TMB-8 · HCl
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关于此项目
线性分子式:
(CH3O)3C6H2CO2(CH2)8N(C2H5)2 · HCl
化学文摘社编号:
分子量:
431.99
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
258-574-5
Beilstein/REAXYS Number:
5466611
MDL number:
产品名称
8-(二乙氨基)辛基-3,4,5-三甲氧基苯甲酸酯 盐酸盐, ≥98%
InChI
1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H
InChI key
KFJZVXKPPQIYCG-UHFFFAOYSA-N
SMILES string
Cl[H].CCN(CC)CCCCCCCCOC(=O)c1cc(OC)c(OC)c(OC)c1
assay
≥98%
form
powder
mp
94-97 °C (lit.)
Quality Level
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Application
- 丙型肝炎病毒生命周期的药理活性抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Byung-Hwan Lee et al.
Biological & pharmaceutical bulletin, 32(5), 861-867 (2009-05-08)
Previous reports have shown that diltiazem and TMB, calcium channel antagonists, inhibit 5-hydroxytryptamine type 3A (5-HT(3A)) receptor-mediated currents (I(5-HT)) in cell lines and in heterologously expressed Xenopus oocytes. In the present study, we sought to elucidate the molecular mechanisms underlying
Patrycja Libako et al.
Magnesium research, 25(1), 12-20 (2012-03-30)
Divalent cations, especially calcium and magnesium, have been shown to play an important regulatory role in endothelial and immune cells. To learn more about the interaction of these two metals in the regulation of cell growth, we altered the calcium/magnesium
Jafar Vatanparast et al.
European journal of pharmacology, 571(2-3), 81-87 (2007-06-30)
We have previously reported that paraoxon, an organophosphate compound, at submicromolar concentrations effectively suppresses Ca2+ action potentials and modulates the activity of snail neurons. This effect was unrelated to acetylcholinesterase inhibition but was found to involve the direct or indirect
Agata Adamczyk et al.
Folia neuropathologica, 43(3), 139-142 (2005-10-26)
Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol
Byung-Hwan Lee et al.
Neuropharmacology, 52(4), 1139-1150 (2007-01-30)
We previously demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active components of Panax ginseng, non-competitively inhibits 5-HT(3A) receptor channel activity on extracellular side of the cell. Here, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced 5-HT(3A) receptor regulation.
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