Quality Level
assay
≥90%
form
powder
storage temp.
−20°C
SMILES string
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
InChI
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
InChI key
UOWZUVNAGUAEQC-UHFFFAOYSA-N
Gene Information
human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)
Application
- 甲状腺激素研究：研究3,3′,5-三碘甲腺乙酸对MCT8缺陷患者的外周和神经发育影响，说明它的甲状腺相关发育疾病的治疗潜力(Unsal and Hayran, 2024)。
- 神经疾病治疗：研究用3,3′,5-三碘甲腺乙酸解决Allan-Herndon-Dudley综合征模拟大脑类器官的T3摄入和作用异常，为治疗大脑特异性甲状腺激素转运异常提供依据(Salas-Lucia et al., 2024)。
- 抗病毒治疗的药物发展：Tiratricol是3,3′,5-三碘甲腺乙酸的衍生物，研究发现它可通过靶向依赖病毒RNA的RNA聚合酶抑制黄热病毒复制，显示抗病毒药物开发潜力(Ren et al., 2023)。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
Leandro Martínez et al.
Journal of medicinal chemistry, 49(1), 23-26 (2006-01-06)
Steered molecular dynamics simulations of ligand dissociation from Thyroid hormone receptors indicate that dissociation is favored via rearrangements in a mobile part of the LBD comprising H3, the loop between H1 and H2, and nearby beta-sheets, contrary to current models
Rie Anzai et al.
Thyroid : official journal of the American Thyroid Association, 22(10), 1069-1075 (2012-09-06)
The effectiveness of short-term 3,5,3'-triiodothyroacetic acid (TRIAC) therapy for the treatment of hyperthyroidism caused by thyroid hormone resistance (RTH) has been documented. Here, we report a 3-year course of TRIAC therapy in an RTH boy, with a quantitative evaluation of
Wim Klootwijk et al.
Endocrinology, 152(8), 3259-3267 (2011-06-10)
Thyroid hormone (TH) is important for metamorphosis in many species, including the cephalochordate Branchiostoma floridae, a marine invertebrate (amphioxus) living in warmer coastal areas. Branchiostoma expresses a TH receptor, which is activated by 3,3',5-triiodothyroacetic acid (TA(3)) but not by T(3).
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T7650-1G | 04061825928876 |
| T7650-100MG | 04061837378492 |
| T7650-500MG | 04061832622323 |