W239607
丁二酸二甲酯
98%, FG
别名:
丁二酸二甲酯, 琥珀酸二甲酯
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关于此项目
线性分子式:
CH3OCOCH2CH2COOCH3
化学文摘社编号:
分子量:
146.14
FEMA Number:
2396
Council of Europe no.:
439
UNSPSC Code:
12164502
PubChem Substance ID:
Flavis number:
9.445
EC Number:
203-419-9
NACRES:
NA.21
MDL number:
Beilstein/REAXYS Number:
956776
Organoleptic:
green; fruity; floral; sweet
Grade:
FG, Halal, Kosher
Biological source:
synthetic
Food allergen:
no known allergens
SMILES string
COC(=O)CCC(=O)OC
InChI
1S/C6H10O4/c1-9-5(7)3-4-6(8)10-2/h3-4H2,1-2H3
InChI key
MUXOBHXGJLMRAB-UHFFFAOYSA-N
biological source
synthetic
grade
FG, Halal, Kosher
reg. compliance
EU Regulation 1334/2008 & 178/2002, FDA 21 CFR 117, FDA 21 CFR 172.515
vapor pressure
0.3 mmHg ( 20 °C)
assay
98%
autoignition temp.
689 °F
expl. lim.
8.5 %
refractive index
n20/D 1.419 (lit.)
bp
200 °C (lit.)
mp
16-19 °C (lit.)
density
1.117 g/mL at 25 °C (lit.)
application(s)
flavors and fragrances
documentation
see Safety & Documentation for available documents
food allergen
no known allergens
organoleptic
green; fruity; floral; sweet
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General description
丁二酸二甲酯可作为调味剂用于食品工业。
Application
- 代谢旁路挽救了阿尔茨海默病患者神经元中异常S-亚硝基化诱导的TCA循环抑制和突触损失。: 这项研究讨论了琥珀酸二甲酯之类的代谢中间体在规避阿尔茨海默病生化阻滞中的作用，提供了潜在的治疗途径（Andreyev et al., 2024）。
- RIFM香精成分安全性评估更新，丁二酸二甲酯，CAS等级号码106-65-0。: 作为香精成分的丁二酸二甲酯的全面安全评估，强调了其毒理学特征和安全使用参数（Api et al., 2023）。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
201.2 °F - closed cup
flash_point_c
94 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Burdock, GA
Encyclopedia of Food and Color Additives, 1, 878-879 (1997)
V Leclercq-Meyer et al.
Biochemical and molecular medicine, 59(1), 87-90 (1996-10-01)
Glucagon-like peptide 1 (GLP-1) is often referred to as a glucose-dependent insulinotropic agent and is currently under investigation as a tool in the treatment of noninsulin-dependent diabetes. This report shows that, in the absence of glucose, a nonglucidic nutrient, namely
Shohei Hamada et al.
Bioorganic & medicinal chemistry letters, 19(10), 2852-2855 (2009-04-11)
N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted
V Leclercq-Meyer et al.
Life sciences, 58(14), 1195-1199 (1996-01-01)
The glucagon-like peptide 1 (7-36) amide (GLP-1, 1.0 nM) was administered to isolated rat pancreases perfused either in the absence of exogenous nutrient or presence of 10 mM succinic acid dimethyl ester (SAD). In the absence of any exogenous nutrient
L Ladrière et al.
Metabolism: clinical and experimental, 48(1), 102-106 (1999-01-27)
The metabolism of [2,3-13C]succinic acid dimethyl ester ([2,3-13C]-SAD) 10 mmol/L was examined in hepatocytes from overnight-fasted normal rats, 3-day starved rats, and overnight-fasted hereditarily diabetic Goto-Kakizaki (GK) rats. The amount of 13C-labeled succinate, fumarate, malate, lactate, alanine, and aspartate released
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