W290904
胡椒碱
≥95%, FG
别名:
1-胡椒酰哌啶
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关于此项目
经验公式（希尔记法）:
C17H19NO3
化学文摘社编号:
分子量:
285.34
FEMA编号:
2909
Beilstein:
90741
EC 号:
欧洲委员会编号:
492
MDL编号:
UNSPSC代码:
12164502
PubChem化学物质编号:
Flavis编号:
14.003
NACRES:
NA.21
生物来源
Piper nigrum L.
等级
FG
Halal
Kosher
管理合规性
EU Regulation 1334/2008 & 178/2002
FDA 21 CFR 172.515
方案
≥95%
表单
powder, crystals or granules
mp
131-135 °C (lit.)
应用
flavors and fragrances
文件
see Safety & Documentation for available documents
食品过敏原
no known allergens
性状检查
fatty; pepper
SMILES字符串
O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3
InChI
1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChI key
MXXWOMGUGJBKIW-YPCIICBESA-N
基因信息
human ... CYP3A4(1576)
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生化/生理作用
Piperine, a major component of black pepper extracts, shown to have potential for inhibiting fat cell formation.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Janine Zaugg et al.
Journal of natural products, 73(2), 185-191 (2010-01-21)
A plant extract library was screened for GABA(A) receptor activity making use of a two-microelectrode voltage clamp assay on Xenopus laevis oocytes. An ethyl acetate extract of black pepper fruits [Piper nigrum L. (Piperaceae) 100 microg/mL] potentiated GABA-induced chloride currents
Ui-Hyun Park et al.
Journal of agricultural and food chemistry, 60(15), 3853-3860 (2012-04-03)
This study investigated the antiadipogenic activity of black pepper extract and its constituent piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both black pepper extract and piperine, without affecting cytotoxicity, strongly inhibited the adipocyte differentiation of 3T3-L1
Paul B Yaffe et al.
Experimental and molecular pathology, 94(1), 109-114 (2012-10-16)
Piperine, an alkaloid phytochemical found in the fruit of black and long pepper plants, is reported to inhibit the growth of cancer cells; however, the mechanism of action in human cancer cells is not clear. In this study we investigated
Hyejeong Jwa et al.
Biochemical pharmacology, 84(11), 1501-1510 (2012-09-25)
This study investigated the role of piperine in the transcriptional regulation of liver X receptor α (LXRα) and the effects of dietary piperine on high-fat diet (HFD)-induced hepatic steatosis and insulin resistance in mice. Furthermore, we explored the potential molecular
Sophia Khom et al.
Biochemical pharmacology, 85(12), 1827-1836 (2013-04-30)
The action of piperine (the pungent component of pepper) and its derivative SCT-66 ((2E,4E)-5-(1,3-benzodioxol-5-yl))-N,N-diisobutyl-2,4-pentadienamide) on different gamma-aminobutyric acid (GABA) type A (GABA(A)) receptors, transient-receptor-potential-vanilloid-1 (TRPV1) receptors and behavioural effects were investigated. GABA(A) receptor subtypes and TRPV1 receptors were expressed in
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