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Merck
CN

W323713

2,3,5,6-四甲基吡嗪

greener alternative

natural, ≥98%, FG

别名:

四甲基吡嗪碱, 川芎嗪

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关于此项目

经验公式（希尔记法）:
C8H12N2
化学文摘社编号:
1124-11-4
分子量:
136.19
Flavis number:
14.018
PubChem Substance ID:
24901576
UNSPSC Code:
12164502
FEMA Number:
3237
NACRES:
NA.21
EC Number:
214-391-2
MDL number:
MFCD00006146
Beilstein/REAXYS Number:
113100
Organoleptic:
chocolate; coffee; fatty; musty; nutty
Grade:
FG
Fragrance grade
Halal
Kosher
natural
Agency:
follows IFRA guidelines
meets purity specifications of JECFA
Food allergen:
no known allergens

主要文件

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产品名称

2,3,5,6-四甲基吡嗪, natural, ≥98%, FG

InChI key

FINHMKGKINIASC-UHFFFAOYSA-N

InChI

1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

SMILES string

Cc1nc(C)c(C)nc1C

grade

FG
Fragrance grade
Halal
Kosher
natural

agency

follows IFRA guidelines
meets purity specifications of JECFA

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 178/2002

assay

≥98%

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤2.0% water (Karl Fischer)

bp

190 °C (lit.)

mp

77-80 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

greener alternative category

, Aligned

organoleptic

chocolate; coffee; fatty; musty; nutty

Quality Level

300
400

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相关类别

Application


  • 2,3,5,6-四甲基吡嗪和紫外光的结合能有效地吸引嗜脂虫。：该研究表明，2,3,5,6-四甲基吡嗪和紫外线的组合有效地吸引了书虫，这表明在储存产品环境中害虫管理的潜在应用（Tanaka et al., 2024）。

  • 2,3,5,6-四甲基吡嗪通过调节ATF4介导的PRP聚集抑制来保护视网膜光感受器免受内质网应激。：该研究强调了2,3,5,6-四甲基吡嗪的神经保护作用，显示其通过保护光感受器免受应激性损伤来治疗视网膜疾病的潜力（Huang et al., 2021）。

  • 约氏红球菌的TMP1四甲基吡嗪诱导启动子区。：该研究在约氏红球菌TMP1中发现了一个由四甲基吡嗪诱导的启动子区域，可用于基因工程和生物技术应用（Stanislauskienė et al., 2018）。

General description

2，3，5，6-四甲基吡嗪是烤可可豆和枫糖浆中的主要挥发性香气化合物之一。
我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品为生物基产品，在“危险性较小的化学合成”和“使用可再生原料”绿色化学原则方面取得了重大进步。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBT0019
SHBS8343
SHBR6644
SHBS0294
SHBQ8589

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Quantitation of alkylpyrazines in maple syrup, maple flavors and non-maple syrups.
Akochi-KE, et al.
Food Research International, 27(5), 451-457 (1994)
Donghui Xu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(5), 2012-2021 (2018-09-24)
Ligustrazine (LSZ) has been identified as an antitumor agent against some types of cancers. Nevertheless, its ability to inhibit growth, migration and invasion of medulloblastoma cells is still unclear. This study aimed to explore the effect of LSZ on Daoy
Hongfei Chen et al.
European journal of medicinal chemistry, 46(11), 5609-5615 (2011-10-14)
A series of novel ligustrazinyloxy-cinnamic acid derivatives were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro, and also assayed for their protective effect against hydrogen peroxide (H(2)O(2))-induced oxidative damage on ECV-304 cells.
Xian-Chao Cheng et al.
Bioorganic & medicinal chemistry, 15(10), 3315-3320 (2007-03-27)
A series of novel Ligustrazine derivatives was designed, synthesized, and assayed for their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities. The results showed that most Ligustrazine derivatives exhibited lower EC(50) values for protective effects on the ECV-304
Xian-Chao Cheng et al.
Bioorganic & medicinal chemistry, 17(8), 3018-3024 (2009-03-31)
A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged
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