W425001
哌嗪
99%
别名:
二乙烯二胺, 对二氮己环
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关于此项目
经验公式（希尔记法）:
C4H10N2
化学文摘社编号:
分子量:
86.14
Flavis number:
14.141
PubChem Substance ID:
UNSPSC Code:
12164502
FEMA Number:
4250
EC Number:
203-808-3
MDL number:
Beilstein/REAXYS Number:
102555
InChI
1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
SMILES string
C1CNCCN1
InChI key
GLUUGHFHXGJENI-UHFFFAOYSA-N
biological source
synthetic
vapor pressure
0.8 mmHg ( 20 °C)
assay
99%
expl. lim.
14 %
bp
145-146 °C (lit.)
mp
109-112 °C (lit.)
solubility
H2O: 0.9 g/L at 20 °C
application(s)
flavors and fragrances
organoleptic
camphoraceous
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signalword
Danger
Hazard Classifications
Eye Dam. 1 - Flam. Sol. 1 - Repr. 2 - Resp. Sens. 1B - Skin Corr. 1B - Skin Sens. 1B
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 1
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Slavka Hamulakova et al.
European journal of medicinal chemistry, 55, 23-31 (2012-07-24)
New tacrine derivatives 5a-d, 6a-d with piperazino-ethyl spacer linked with corresponding secondary amines and tacrine homodimer 8 were synthesized and tested as cholinesterase inhibitors on human acetylcholinesterase (hAChE) and human plasmatic butyrylcholinesterase (hBChE). In most cases the majority of synthesized
Enza Lacivita et al.
Journal of medicinal chemistry, 55(14), 6375-6380 (2012-06-29)
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT(7) affinities in the
Mitsunori Kono et al.
Bioorganic & medicinal chemistry, 21(1), 28-41 (2012-12-12)
A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the lead compound 3
R A Lovell
The Veterinary clinics of North America. Small animal practice, 20(2), 453-468 (1990-03-01)
Review of all reports involving anthelmintics in dogs and cats to the IAPIC between January 1, 1986 and August 10, 1988, revealed that ivermectin (extra-label use) and piperazine accounted for over 50% of the calls assessed as toxicoses and suspected
Yuji Nakamura et al.
Bioorganic & medicinal chemistry letters, 22(14), 4561-4566 (2012-06-26)
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability
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