产品名称
Sulfatides (Brain), Avanti Research™ - A Croda Brand
InChI
1S/C48H93NO11S.H3N/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48;/h35,37,41-43,45-48,50-51,53-54H,3-34,36,38-40H2,1-2H3,(H,
InChI key
DVNDZUUWWJPMSI-RYBIKTNWSA-N
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]
description
Sulfatides (Brain, Porcine) (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (131305P-10mg)
pkg of 1 × 25 mg (131305P-25mg)
pkg of 1 × 5 mg (131305P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Packaging
5 mL Amber Glass Screw Cap Vial (131305P-25mg)
5 mL Amber Glass Screw Cap Vial (131305P-5mg)
5 mL Amber Glass Screw Cap Vial (131305P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Application
Sulfatides (Brain) has been used:
- as a lipid standard in electrospray ionization (ESI)-MS/MS analysis, as an anionic amphiphile for large unilamellar vesicles (LUVs) preparation
- to test its myelin-associated axon growth inhibition functionality in retinal ganglion cells
- as a calibrant in tandem mass spectrometry to quantify mouse brain myelin samples
Biochem/physiol Actions
Elevated sulfatides levels are implicated in renal, ovarian and adenocarcinoma. Accumulation of sulfatides in events of arylsulfatase A enzyme deficiency leads to metachromatic leukodystrophy, a lysosomal storage disease. Sulfatide is a myelin-associated inhibitor of axon growth and is implicated in the axon regenerative failure. It is a multifunctional sulfolipid, which plays a key role in immune response and insulin secretion. It binds to fibrinogen and elicits anticoagulant activity. Sulfatides are elevated in Parkinson′s disease and is a target for nervous disorder treatment. Sulfatideis also an inhibitor of oligodendrocyte differentiation. Sulfatides are utilized by bacteria for their adherence into host cells. They are responsible for the inflammatory responses in chronic central nervous system illness.
General description
Sulfatides are majorly present in the brain and plasma membrane, especially in the outer leaflet. They are anionic sulfoglycolipids synthesized by oligodendrocytes and are the prime component of myelin sheath. It constitutes 4 -7% weight of the myelin lipid. Sulfatides are also associated with non-neural tissues including gall bladder, colon and kidney. In the Golgi, 3′-phosphoadenosine5′phosphosulfate:cerebrosidesulfo transferase mediates the synthesis of sulfatides by 3-O-sulfation of the galactosylceramide. Lysosomes are the catabolism site for sulfatides, wherein arylsulfatase A mediates their breakdown.
This Natural Lipid is a mixture, and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
存储类别
11 - Combustible Solids
法规信息
涉药品监管产品
此项目有
Reproduction of vesicles coupled with a vesicle surface-confined enzymatic polymerisation
Kurisu M, et al.
Communications Chemistry, 2(1), 1-10 (2019)
A comprehensive profiling of sulfatides in myelin from mouse brain using liquid chromatography coupled to high-resolution accurate tandem mass spectrometry
Pintado-Sierra M, et al.
Analytica Chimica Acta, 951(1), 89-98 (2017)
Role of sulfatide in normal and pathological cells and tissues
Takahashi T and Suzuki T
Journal of Lipid Research, 53(8), 1437-1450 (2012)
The lipid sulfatide is a novel myelin-associated inhibitor of CNS axon outgrowth
Winzeler AM, et al.
Journal of nanoneuroscience, 31(17), 6481-6492 (2011)
Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells
Jeon SB, et al
Journal of Immunology, 181(11), 8077-8087 (2008)
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