产品名称
Brain Extract Polar, Avanti Research™ - A Croda Brand
assay
>99% (TLC)
form
chloroform solution
packaging
pkg of 1 × 4 mL (141101C-100mg)
pkg of 5 × 4 mL (141101C-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
25 mg/mL (141101C-100mg)
25 mg/mL (141101C-500mg)
lipid type
lipid extracts
shipped in
dry ice
storage temp.
−20°C
Application
Brain Extract Polar has been used as an artificial membrane solution component for permeability studies. It may be used for coating donor plate during parallel artificial membrane permeability assay (PAMPA) to study blood-brain barrier penetration. It may be used in liposome preparation for dynamin self-assembly assay.
Biochem/physiol Actions
Brain lipid, especially the polar fraction plays a key role in the inhibition of prion seeded amyloid formation. Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.
General description
Brain Extract Polar comprises phosphatidylethanolamine as major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.
Packaging
5 mL Clear Glass Sealed Ampule (141101C-100mg)
5 mL Clear Glass Sealed Ampule (141101C-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Kalirin12 interacts with dynamin
Xin X, et al.
BMC Neuroscience, 10(1), 61-61 (2009)
Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
Vucicevic J, et al.
European Journal of Pharmaceutical Sciences, 68(10), 94-105 (2015)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito TPC, et al.
European Journal of Medicinal Chemistry, 145(10), 431-444 (2018)
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
Irene Paterniti et al.
PloS one, 6(1), e15937-e15937 (2011-02-08)
Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持