产品名称
E06 单克隆抗体, E06 Mouse Monoclonal Antibody (IgM), Anti-(Oxidized Phospholipid), 1X PBS (Phosphate Buffered Saline) with 0.27 mM Na2 EDTA
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
assay
>95%
form
solution
packaging
pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330001S-100ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 330001S
concentration
1 mg/mL (330001S-100ug)
shipped in
dry ice
storage temp.
−70°C
General description
E06抗体是一种小鼠单克隆IgM天然抗体，其与氧化磷脂结合并与氧化LDL、氧化HDL以及由氧化磷脂共价修饰的蛋白质反应。每批次都经过活性验证，并提供有关上述应用的详细实验方案。E06抗体是由加利福尼亚大学圣地亚哥分校的Joseph Witztum博士通过使用载脂蛋白E敲除小鼠喂食高脂饮食七个月开发出来的。
Application
E06单抗已用作氧化损伤的检测标记。
E06抗体已被用于检测小鼠、斑马鱼、兔、猴和人的动脉粥样硬化斑块。它还能够与凋亡细胞结合，但不与活细胞结合，并且适用于多种应用，包括ELISA、免疫组织化学和蛋白质免疫印迹分析，以及用MRI体内成像技术。
Packaging
0.5 mL聚丙烯管，带螺旋盖（330001S-100ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
S Hörkkö et al.
The Journal of clinical investigation, 103(1), 117-128 (1999-01-12)
We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies). We now demonstrate that those EO- autoantibodies that were originally selected for binding to copper-oxidized low-density lipoproteins (CuOx-LDL), also bound
J Qin et al.
Journal of neuroscience research, 85(5), 977-984 (2007-02-17)
Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1-palmitoyl-2-(5'-oxo)valeryl-sn-glycero-3-phosphorylcholine (POVPC)], a lipid associated with
Peter Friedman et al.
The Journal of biological chemistry, 277(9), 7010-7020 (2001-12-18)
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis through a variety of pathways. The process involves nonspecific fragmentation, oxidative breakdown, and modification of the lipids and protein of LDL. The process yields a variety of bioactive
W Palinski et al.
The Journal of clinical investigation, 98(3), 800-814 (1996-08-01)
Many reactive products may be formed when LDL undergoes lipid peroxidation, which in turn can react with lipids, apoproteins, and proteins, generating immunogenic neoepitopes. Autoantibodies recognizing model epitopes of oxidized low density lipoprotein, such as malondialdehydelysine, occur in plasma and
Sotirios Tsimikas et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(1), 175-181 (2006-11-04)
Oxidized phospholipids (OxPL) are pro-inflammatory. We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression. OxPL content was measured in plasma and
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