640000P
Avanti
DMABA-d0 NHS Ester
Avanti Research™ - A Croda Brand
别名:
4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d0
描述
4-(dimethylamino)-2,5-dioxo-1-pyrrolidinyl ester benzoic acid
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 50 mg (640000P-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
InChI
1S/C13H14N2O4/c1-14(2)10-5-3-9(4-6-10)13(18)19-15-11(16)7-8-12(15)17/h3-6H,7-8H2,1-2H3
InChI key
FNGFZOAQGYOQTG-UHFFFAOYSA-N
一般描述
The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
生化/生理作用
DMABA-d0 NHS Ester, deuterium enriched 4-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents (d0) is used for derivatizing the primary amine group of lipids, such as glycerophosphoethanolamine (PE) lipid species and differential labeling. It enables detection of phosphatidylethanolamine subclasses in biological samples.
包装
5 mL Amber Glass Screw Cap Vial (640000P-50mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and
Karin A Zemski Berry et al.
Analytical chemistry, 81(16), 6633-6640 (2010-03-27)
A set of four (D(0), D(4), D(6), and D(10)) deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) lipids to create derivatives where all subclasses of DMABA labeled
Marko Kosicek et al.
International journal of molecular sciences, 14(1), 1310-1322 (2013-01-12)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
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