SMILES string
CN(C)C1=C([2H])C([2H])=C(C(ON(C(CC2)=O)C2=O)=O)C([2H])=C1[2H]
description
4-(dimethylamino)-2,5-dioxo-1-pyrrolidinyl ester-benzoic-2,3,5,6-d4 acid
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (640004P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
Biochem/physiol Actions
DMABA-d4 NHS Ester is a deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagent. It helps in assessing distribution of phosphatidylethanolamine in RAW 264.7 cells. DMABA-d4 NHS ester is used for derivatization studies. DMABA esters enable lipid quantification and profiling during biological events.
Deuterium enriched 4-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents (d0, d4, d6, d10) derivatize the primary amine group of lipids, such as glycerophosphoethanolamine (PE) lipid species.
Packaging
5 mL Amber Glass Screw Cap Vial (640004P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant
Wynalda KM and Murphy RC
Chemical Research in Toxicology, 23(1), 108-117 (2009)
Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Marko Kosicek et al.
International journal of molecular sciences, 14(1), 1310-1322 (2013-01-12)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels
Karin A Zemski Berry et al.
Analytical chemistry, 81(16), 6633-6640 (2010-03-27)
A set of four (D(0), D(4), D(6), and D(10)) deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) lipids to create derivatives where all subclasses of DMABA labeled
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持