产品名称
DMABA-d10 NHS Ester, Avanti Research™ - A Croda Brand
SMILES string
O=C(ON(C(CC1)=O)C1=O)C2=C([2H])C([2H])=C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])=C2[2H]
description
4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic-2,3,5,6-d4 acid
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (640010P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
DMABA-d10 NHS Ester, deuterium enriched 10-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagent (d10) is used for derivatizing the primary amine group of PE lipids for differential labeling. It is useful in lipid research. Structurally it has 6 hydrogen atoms deuterated in the 2 methyl groups and 4 hydrogen atoms deuterated in the aromatic ring. d10-DMABA NHS enables detection of phosphatidylethanolamine subclasses in biological samples by tandem mass spectrometry.
General description
The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
Packaging
5 mL Amber Glass Screw Cap Vial (640010P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Marko Kosicek et al.
International journal of molecular sciences, 14(1), 1310-1322 (2013-01-12)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and
Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Karin A Zemski Berry et al.
European journal of mass spectrometry (Chichester, England), 16(3), 463-470 (2008-01-01)
Recently, a derivative of PE, namely the 4-(dimethylamino)benzoic acid derivative has been developed with various isotope labeled variants that provided a universal precursor ion scan for diacyl, ether and plasmalogen PE lipids that can not be accomplished otherwise. This derivative
Karin A Zemski Berry et al.
Analytical chemistry, 81(16), 6633-6640 (2010-03-27)
A set of four (D(0), D(4), D(6), and D(10)) deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents was developed that react with the primary amine group of glycerophosphoethanolamine (PE) lipids to create derivatives where all subclasses of DMABA labeled
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