产品名称
Kdo2-Lipid A (KLA), Avanti Research™ - A Croda Brand
SMILES string
O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO[C@]2(C([O-])=O)C[C@@H](O[C@@]3(C([O-])=O)O[C@H]([C@H](O)CO)[C@H](O)[C@H](O)C3)[C@@H](O)[C@@H]([C@H](O)CO)O2)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCC
description
Di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt)
assay
>99% (HPLC)
form
powder
packaging
pkg of 1 × 1 mg (699500P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
lipidomics
lipid type
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
Application
Kdo2脂质A（KLA）已被用于研究其在脂多糖诱导的朊蛋白转化中的作用。
Kdo2脂质A（KLA）已被用作：
- 永生化小鼠巨噬细胞培养介质中的toll样受体（TLR）配体源
- 在1,2-二己酰基-sn-甘油-3-磷酸胆碱（DHPC）胶束中2H-,13C-,15N标记的的OprHΔL1ΔL4，确定与脂多糖（LPS）源相互作用的OprHΔL1ΔL4的特定残基
- 作为脂多糖（LPS）原液的一种组分，以研究其在脂多糖诱导的朊蛋白转化中的作用
Biochem/physiol Actions
Kdo2脂质A可能有助于刺激炎症反应。
General description
Kdo2脂质A是一种天然内毒素，是低聚糖和脂质的混合物。
糖脂聚糖的新制剂Kdo2脂质A（KLA）是一种几乎均匀的再脂多糖（LPS）亚结构，其内毒素活性与天然LPS相当。KLA与LPS相当，其在TLR-4缺陷小鼠细胞中的活性降低>103。与LPS相比，KLA的优势在于它是一种可重复的、确定的天然产物，并且可以在用于刺激动物细胞的低浓度下通过ESI/MS检测到。KLA的纯度也有助于，其与信号受体（如TLR-4/MD2）复合物进行结构分析。新的研究*表明1μg KLA诱导的反应与10μg LPS相同。以使用LPS的一半成本进行实验！
Other Notes
仅供研发使用。& 不可用于药物、家庭或其他用途。
Packaging
2 mL琥珀色玻璃钳口盖瓶(699500P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages
Maurya MR, et al.
Journal of Lipid Research, 54(9), 2525-2542 (2013)
Molecular interactions of lipopolysaccharide with an outer membrane protein from Pseudomonas aeruginosa probed by solution NMR
Kucharska I, et al.
Biochemistry, 55(36), 5061-5072 (2016)
Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversion
Ladner-Keay CL, et al.
Prion, 10(6), 466-483 (2016)
Hirotaka Sasaki et al.
Biophysical journal, 95(2), 986-993 (2008-04-01)
The innate immune systems of humans and other animals are activated by lipopolysaccharides (LPS), which are glucosamine-based phospholipids that form the outer leaflet of the outer membranes of Gram-negative bacteria. Activation involves interactions of LPS with the innate immunity-receptor comprised
Alexander Y Andreyev et al.
Journal of lipid research, 51(9), 2785-2797 (2010-06-25)
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual lipids. We report an analysis of the subcellular
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