登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C27H39O2D7
化学文摘社编号:
分子量:
409.70
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352100
Assay:
>99% (TLC)
Form:
powder
description
cholest-5-en-3β,7β-diol-d7
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700044P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
Application
7β-hydroxycholesterol-d7 has been used:
- as cholesterol oxidation product for mass spectroscopy analysis
- as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
- as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
- as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification
Biochem/physiol Actions
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.
Packaging
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids