登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H39O2D7
化学文摘社编号:
分子量:
409.70
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141804
产品名称
22(R)-hydroxycholesterol-d7, Avanti Research™ - A Croda Brand
description
cholest-5-ene-3β,22(R)-diol-d7
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700052P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand and is a key for the receptor activation.. 22(R)-HC promotes mesenchymal stem cell osteogenesis along with other oxysterols. It also regulates cholesterol homeostasis and suppresses prostate tumor progression. Low levels of 22(R)-HC is observed in Alzheimer′s disease and may be implicated in neuroinflammation and neurodegenerative diseases.
General description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in the neonate brain. 22(R)-hydroxycholesterol-d7 is a deuterated form of 22(R)-hydroxycholesterol.
Packaging
5 mL Amber Glass Screw Cap Vial (700052P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Combined treatment with 9-cis beta-carotene and 22R-hydroxycholesterol augments cholesterol efflux in macrophages
Mahler L, et al.
Algal research, 44, 101700-101700 (2019)
Megan M Augustin et al.
The Plant journal : for cell and molecular biology, 82(6), 991-1003 (2015-05-06)
Steroid alkaloids have been shown to elicit a wide range of pharmacological effects that include anticancer and antifungal activities. Understanding the biosynthesis of these molecules is essential to bioengineering for sustainable production. Herein, we investigate the biosynthetic pathway to cyclopamine
Jin-Sun Lee et al.
Stem cell research & therapy, 8(1), 276-276 (2017-12-07)
Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This study investigated the effects of the specific oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on
Hyunmi Kim et al.
Biochimica et biophysica acta, 1859(8), 1056-1070 (2016-05-22)
MAP kinase phosphatase (MKP)-1 plays a pivotal role in controlling MAP kinase (MAPK)-dependent (patho) physiological processes. Although MKP-1 gene expression is tightly regulated at multiple levels, the underlying mechanistic details remain largely unknown. In this study, we demonstrate that MKP-1
Chih-Pin Chuu et al.
Anticancer research, 30(9), 3643-3648 (2010-10-15)
Previously, we and other groups reported that liver X receptor (LXR) agonists T0901317, 22(R)-hydroxycholesterol, and 24(S)-hydroxycholesterol suppressed the proliferation of prostate and breast cancer cells. In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持