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关于此项目
经验公式（希尔记法）:
C27H39D7O
化学文摘社编号:
分子量:
393.70
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141804
产品名称
烯胆甾烷醇-d7, Avanti Research™ - A Croda Brand
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700056P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Application
烯胆甾烷醇-d7已被用作用于母乳甾醇定量的气相色谱-质谱（GC-MS）的内标物，和液相色谱-高分辨率质谱（LC-HRMS）分析的内标物。
Biochem/physiol Actions
烯胆甾烷醇水平是胆固醇水平的直接指标，有助于解码代谢缺陷。烯胆甾烷醇水平升高与脑腱黄瘤病（CTX）和烯胆甾烷醇病有关。烯胆甾烷醇5-去饱和酶（SC5D）失活导致烯胆甾烷醇在烯胆甾烷醇病病理学中积累。
General description
烯胆甾烷醇是存在于人母乳中的胆固醇代谢物。烯胆甾烷醇由烯胆甾烷醇5-去饱和酶分解为7-脱氢胆固醇，这是胆固醇的前体。烯胆甾烷醇-d7是烯胆甾烷醇的氘代衍生物。
Packaging
5 mL琥珀色玻璃螺旋盖样品瓶(700056P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
Patrycja A Krakowiak et al.
Human molecular genetics, 12(13), 1631-1641 (2003-06-19)
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Monica Gelzo et al.
Lipids in health and disease, 18(1), 235-235 (2020-01-01)
Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively. The age of the patients suspected of having these disorders is highly variable due to the
Andrea Civra et al.
The Journal of steroid biochemistry and molecular biology, 193, 105424-105424 (2019-07-16)
Oxysterols are cholesterol oxidation derivatives. Those containing an additional hydroxyl group on the side chain of the cholesterol molecule result from a physiological enzymatic synthesis and include the majority of oxysterols present in the circulation. Among these, 25-hydroxycholesterol (25OHC) and
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