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关于此项目
经验公式(希尔记法):
C29H46O
化学文摘社编号:
分子量:
410.67
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
assay
>99% (TLC)
form
powder
InChI key
LFQXEZVYNCBVDO-PBJLWWPKSA-N
SMILES string
O[C@@H]1C([C@H]2[C@](CC1)(C3=C(CC2)C4=CC[C@@H]([C@]4(CC3)C)[C@@H](CCC=C(C)C)C)C)(C)C
InChI
1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1
packaging
pkg of 1 × 1 mg (700077P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−70°C
General description
卵泡液减数分裂激活甾醇(FF-MAS)是所有细胞中胆固醇生物合成途径的中间产物,可能代表指示卵母细胞重新启动减数分裂的生理信号。
Application
FF-MAS已用于:
- 气相色谱/质谱(GC/MS)分析少突胶质前体细胞(OPC)甾醇的标准品
- 作为Dulbecco′s改良eagle培养基(DMEM)补充剂,以测试其对癌细胞活性的影响
- 评估其对LXRβ过表达鳞状癌SCC61细胞的影响
Biochem/physiol Actions
14-去甲基-14-脱氢羊毛甾醇(FF-MAS)首次在女性卵泡液中发现,并在卵母细胞核成熟中起关键作用。FF-MAS水平可能由细胞色素P450家族27亚家族A成员1调节。向卵母细胞补充FF-MAS可促进减数分裂成熟,有利于着床前。然而,FF-MAS的溶解度较低,并迅速代谢为胆固醇。
Packaging
5 mL琥珀色玻璃螺旋盖样品瓶(700077P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Robert J Fakheri et al.
Steroids, 76(3), 211-215 (2010-10-19)
Autoregulation of cholesterol synthesis focuses on the 19 metabolic steps from lanosterol to cholesterol. Although synchronization of their rates of synthesis in all tissues was the paradigm, a known exception occurs in the ovary where a local increase in a
Autoregulation of cholesterol synthesis: Physiologic and pathophysiologic consequences
Fakheri RJ and Javitt NB
Steroids, 76(3), 211-215 (2011)
Endogenous sterol metabolites regulate growth of EGFR/KRAS-dependent tumors via LXR
Gabitova L, et al.
Cell Reports, 12(11), 1927-1938 (2015)
Two syntheses of FF-MAS
Blume T, et al.
Organic Letters, 5(11), 1837-1839 (2003)
A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro
MarinB, et al.
Human Reproduction, 19(10), 2340-2344 (2004)
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