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经验公式（希尔记法）:
C27H37D7O2
化学文摘社编号:
分子量:
407.68
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141804
产品名称
7α-羟基胆甾烯酮-d7, 7α-hydroxy-4-cholesten-3-one-d7, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700112P-1mg)
pkg of 1 × 10 mg (700112P-10mg)
pkg of 1 × 5 mg (700112P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700112P
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
7α-羟基-4-胆甾烯-3-酮，由酶7α-羟基胆甾-4-烯-3-酮12α-羟化酶代谢为7α,12α-二羟基胆甾-4-烯-3-酮，然后再代谢为胆酸，胆酸是人类主要的初级胆汁酸。或者，它可以转化为5β-胆甾烷-3α,7α-二醇，然后转化为鹅去氧胆酸，这是人类的另一种主要原代胆汁酸。血清7α-羟基-4-胆甾烯-3-酮浓度反映胆汁酸合成途径的活性。血清7α-羟基-4-胆甾烯-3-酮值在白天变化，因为胆汁酸合成速率具有昼夜节律。胆汁酸吸收不良患者中测得的7α-羟基-4-胆甾烯-3-酮值升高。这可能有助于诊断这种情况，因为高值与低75硒高胆酸牛磺酸（SeHCAT）滞留有关。7α-羟基-4-胆甾烯-3-酮在伴有腹泻的肠易激综合征（IBS-D）中水平升高。氘标记的7α-羟基-4-胆甾烯-3-酮（d7-7αC4）用作液相色谱-串联质谱（LC-MS/MS）测量中的内标物。
General description
7α-羟基-4-胆甾烯-3-酮是胆固醇生化合成胆汁酸的中间体。其前体7α-羟基胆固醇由肝脏胆固醇7α-羟化酶（CYP7A1）从胆固醇中产生。[1]它由酶7α-羟基胆甾-4-烯-3-酮12α-羟化酶代谢为7α,12α-二羟基胆甾-4-烯-3-酮，然后再代谢为胆酸，胆酸是人类主要的原胆汁酸。或者，它可以转化为5β-胆甾烷-3α,7α-二醇，然后转化为鹅去氧胆酸，这是人类的另一种主要原代胆汁酸。血清7α-羟基-4-胆甾烯-3-酮浓度反映胆汁酸合成途径的活性。血清7α-羟基-4-胆甾烯-3-酮值在白天变化，因为胆汁酸合成速率具有昼夜节律。[2] 胆汁酸吸收不良的患者中发现升高值，这可能有助于诊断这种情况，因为高值与低SeHCAT潴留有关。[3] 血清7α-羟基-4-胆甾烯-3-酮浓度的增加反映了胆汁酸吸收不良引起的胆汁酸损失，或在原发性胆汁酸腹泻中发现的合成增加，与FGF19对CYP7A1的负反馈受损有关。[4]
Packaging
5 mL琥珀色玻璃螺旋盖样品瓶(700112P-1mg)
5 mL琥珀色玻璃螺旋盖样品瓶(700112P-5mg)
5 mL琥珀色玻璃螺旋盖样品瓶（700112P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
M Camilleri et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 21(7), 734-e43-734-e43 (2009-04-17)
Bile acid malabsorption (BAM) is reported in up to 50% of patients with functional diarrhoea and irritable bowel syndrome with diarrhoea (IBS-D). Serum 7alpha-hydroxy-4-cholesten-3-one (7alphaHCO or 7alphaC4), an indirect measurement of hepatic bile acid synthesis, has been validated as a
The enzymes, regulation, and genetics of bile acid synthesis. Annual review of biochemistry
Russell DW
Annual Review of Biochemistry, 72, 137-174 (2003)
W Gordon Brydon et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 25(6), 319-323 (2011-07-19)
Bile acid malabsorption (BAM) is a recognized cause of watery diarrhea, often diagnosed empirically based on clinical response to cholestyramine. The radionuclide selenium-labelled homocholic acid-taurine whole body retention test is expensive, labour intensive and of limited availability. To report on
Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea.
Brydon WG, et al.
European Journal of Gastroenterology & Hepatology, 8(2), 117-123 (1996)
Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.
Hofmann AF, et al.
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 7 (11), 1151-1154 (2009)
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