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关于此项目
经验公式（希尔记法）:
C27H37D7O
化学文摘社编号:
分子量:
391.68
MDL number:
UNSPSC Code:
41141804
NACRES:
NA.25
产品名称
7-去氢胆甾醇-d7, 7-dehydrocholesterol-d7, powder
SMILES string
O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)C3=CC=C2C1)C)C
InChI
1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
InChI key
UCTLRSWJYQTBFZ-UDEPUTHCSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700116P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700116P
shipped in
dry ice
storage temp.
−70°C
Application
7-脱氢胆固醇-d7已被用于：
- 作为内标物：加标衣藻CC-125脂质提取物进行质谱分析
- 用于培养细胞氧化甾醇分析的液相色谱-质谱（LC-MS）中
- 用于气相色谱/质谱（GC/MS）分析用于处理和标记SRD-1细胞（中国仓鼠卵巢（CHO）突变细胞系）
Biochem/physiol Actions
7-脱氢胆固醇（7-DHC）用作微生物维生素D3生产的前体。 7-脱氢胆固醇还原酶（DHCR7）功能受损导致7-DHC积累，并与Smith-Lemli-Opitz综合征（SLOS）有关。
General description
7-脱氢胆固醇（7-DHC）是一种胆固醇前体，位于基底表皮角质形成细胞中。7DHC在紫外光B存在下发生光解生成维生素原D3。脱氢胆固醇还原酶（DHCR7）催化7-DHC的C（7-8）双键还原为胆固醇。7-脱氢胆固醇是7-脱氢胆固醇的氘代衍生物。
Packaging
5 mL琥珀色玻璃螺旋盖小瓶(700116P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
美国出口管控产品
此项目有
Hanul Kim et al.
Frontiers in microbiology, 6, 54-54 (2015-03-12)
Concern about global warming has prompted an intense interest in developing economical methods of producing biofuels. Microalgae provide a promising platform for biofuel production, because they accumulate high levels of lipids, and do not compete with food or feed sources.
Andrzej T Slominski et al.
PloS one, 4(2), e4309-e4309 (2009-02-05)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production
Xiao-Jing Guo et al.
Biotechnology for biofuels, 11, 192-192 (2018-07-22)
7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3. Microbial production of 7-DHC from simple carbon has been recognized as an attractive complement to the traditional
Metabolic Precursor of Cholesterol Causes Formation of Chained Aggregates of Liquid-Ordered Domains.
Galya Staneva et al.
Langmuir : the ACS journal of surfaces and colloids, 32(6), 1591-1600 (2016-01-20)
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between
Anika V Prabhu et al.
The Journal of biological chemistry, 291(16), 8363-8373 (2016-02-19)
Cholesterol is detrimental to human health in excess but is also essential for normal embryogenesis. Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. 7-Dehydrocholesterol reductase (DHCR7) is the terminal enzyme of cholesterol
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