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关于此项目
经验公式（希尔记法）:
C26H43NO2
化学文摘社编号:
分子量:
401.63
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
DMHCA, Avanti Research™ - A Croda Brand 700125P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (700125P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700125P
shipped in
dry ice
storage temp.
−20°C
General description
N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.
Application
DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.
It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.
Biochem/physiol Actions
DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.
Packaging
5 mL Amber Glass Screw Cap Vial (700125P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
11 - Combustible Solids