700130P
Avanti
3β,24S-dihydroxy-5-cholestenoic acid
Avanti Research™ - A Croda Brand
别名:
(25R)-cholest-5-en-26-oic acid,3β,24S-dihydroxy
产品名称
3β,24S-dihydroxy-5-cholestenoic acid, Avanti Research™ - A Croda Brand 700130P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (700130P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 700130P
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H](C1)CC[C@](C1=CC2)(C)C3C2C(CC[C@@H]4[C@H](C)CC[C@H](O)[C@@H](C)C(O)=O)[C@]4(C)CC3
InChI key
XXUCPCOTPNGCMA-ODGUSDSXSA-N
一般描述
3β,24S-dihydroxy-5-cholestenoic acid is a cholestenoic acid (CA). The enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the synthesis of CA in the mitochondria.
生化/生理作用
Cholestenoic acid (CA) is a ligand to nuclear receptor. Based on the structural features, CA may elicit neurotoxic or neuroprotective effects. Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.
包装
5 mL Amber Glass Screw Cap Vial (700130P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
新产品
此项目有
Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse
Crick PJ, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475-105475 (2019)
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S, et al
The Journal of Clinical Investigation, 124, 4829-4842 (2014)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143, 440-442 (2019)
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