产品名称
3β,24S-dihydroxy-5-cholestenoic acid, Avanti Research™ - A Croda Brand 700130P, powder
InChI key
XXUCPCOTPNGCMA-ODGUSDSXSA-N
SMILES string
O[C@H](C1)CC[C@](C1=CC2)(C)C3C2C(CC[C@@H]4[C@H](C)CC[C@H](O)[C@@H](C)C(O)=O)[C@]4(C)CC3
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700130P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700130P
shipped in
dry ice
storage temp.
−20°C
General description
3β,24S-dihydroxy-5-cholestenoic acid is a cholestenoic acid (CA). The enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the synthesis of CA in the mitochondria.
Biochem/physiol Actions
Cholestenoic acid (CA) is a ligand to nuclear receptor. Based on the structural features, CA may elicit neurotoxic or neuroprotective effects. Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.
Packaging
5 mL Amber Glass Screw Cap Vial (700130P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse
Crick PJ, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 195, 105475-105475 (2019)
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S, et al
The Journal of Clinical Investigation, 124, 4829-4842 (2014)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143, 440-442 (2019)
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