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关于此项目
经验公式（希尔记法）:
C30H46N2O3
化学文摘社编号:
分子量:
482.70
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
PhotoClick胆固醇, Hex-5′-ynyl 3β-hydroxy-6-diazirinyl-5α-cholan-24-oate, powder
form
powder
assay
>99% (TLC)
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (700147P-100ug))
pkg of 1 × 250 μg (with stopper and crimp cap (700147P-250ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 700147P
lipid type
click reagents
shipped in
dry ice
storage temp.
−20°C
Application
PhotoClick胆固醇已用于：
- 溶酶体相关膜蛋白1（LAMP1）交联研究
- 在酵母固醇结合蛋白的结合和竞争分析中作为胆固醇的类似物
- 作为与溶酶体整合膜蛋白-2（LIMP-2）胞外域的偶联物
Biochem/physiol Actions
PhotoClick胆固醇用作跟踪胆固醇结合蛋白的探针。铜催化的叠氮化物-炔烃环加成反应是其探针功能的基础。炔基对点击化学性质至关重要。它与反应伙伴的结合是通过光交联介导的。
General description
PhotoClick胆固醇是一种可点击的光反应性甾醇探针，与定量质谱联用，可直接在活细胞中绘制胆固醇-蛋白质相互作用的全局图。除了可与蛋白质反应的紫外线活化交联双吖丙啶基团外，甾醇还含有炔基，通过点击化学将报告基因和亲和标签结合。
PhotoClick胆固醇是胆固醇的合成类似物，具有光反应性。它包含炔烃基团。
Packaging
带塞子和压接盖的2 mL琥珀色血清瓶(700147P-100ug)
带塞子和压接盖的2 mL琥珀色血清瓶(700147P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Neha Chauhan et al.
Yeast (Chichester, England), 37(1), 15-25 (2019-11-24)
Ergosterol is a prominent component of the yeast plasma membrane and essential for yeast cell viability. It is synthesized in the endoplasmic reticulum and transported to the plasma membrane by nonvesicular mechanisms requiring carrier proteins. Oxysterol-binding protein homologues and yeast
May Kwang-Mei Wang et al.
PLoS pathogens, 14(9), e1007322-e1007322 (2018-09-29)
Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to analyze the mechanism of entry. Using a photo-reactive analog that
Saskia Heybrock et al.
Nature communications, 10(1), 3521-3521 (2019-08-08)
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1 that
Jonathan J Hulce et al.
Nature methods, 10(3), 259-264 (2013-02-12)
Cholesterol is an essential structural component of cellular membranes and serves as a precursor for several classes of signaling molecules. Cholesterol exerts its effects and is, itself, regulated in large part by engagement in specific interactions with proteins. The full
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