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经验公式（希尔记法）:
C27H39 D5O3
化学文摘社编号:
分子量:
421.67
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141804
Assay:
>99% (TLC)
Form:
powder
产品名称
cholestenoic acid-d5, Avanti Research™ - A Croda Brand 700151P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700151P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700151P
shipped in
dry ice
storage temp.
−20°C
General description
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.
Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Biochem/physiol Actions
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.
Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Packaging
5 mL Amber Glass Screw Cap Vial (700151P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Cholestenoic acid, an endogenous cholesterol metabolite, is a potent gamma-secretase modulator
Jung JI, et al.
Mol. Neurodegener., 10(1), 29-29 (2015)
Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha
Song C and Liao S
Endocrinology, 141(11), 4180-4184 (2000)
Diseases of the Liver in Children (2014)
Cholestenoic acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain
Mast N, et al.
Investigative Ophthalmology & Visual Science, 52(1), 594-603 (2011)
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