产品名称
20α-hydroxycholesterol, Avanti Research™ - A Croda Brand 700156P, powder
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@](O)(CCCC(C)C)C)(CC3)C)CC=C2C1)C
InChI
1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1
InChI key
MCKLJFJEQRYRQT-APGJSSKUSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (700156P-10mg)
pkg of 1 × 5 mg (700156P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700156P
shipped in
dry ice
storage temp.
−20°C
Application
20α-hydroxycholesterol or 5-cholestene-3α,20α-diol has been used to study the role of oxysterols on mammalian immune function.
Packaging
5 mL Amber Glass Screw Cap Vial (700156P-10mg)
5 mL Amber Glass Screw Cap Vial (700156P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease
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