产品名称
猪胆酸, Avanti Research™ - A Croda Brand
SMILES string
O[C@H]1[C@@H]2[C@@H]([C@@]4([C@H]([C@H]1O)C[C@@H](CC4)O)C)CC[C@]3([C@H]2CC[C@@H]3[C@@H](CCC(=O)O)C)C
InChI
1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21-,22+,23-,24-/m1/s1
InChI key
DKPMWHFRUGMUKF-KWXDGCAGSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (700159P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
bile acids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
胆汁淤积性肝病和肝硬化患者血浆和尿液样品中的猪胆酸水平上升。
General description
猪胆酸又名3α,6α,7α-三羟基-5β-脱氧胆酸，通过鹅脱氧胆酸的6α-羟化反应合成。它是猪体内主要的三羟基化胆汁酸。在人体胆汁酸中也有少量存在。猪胆酸也可在肝脏中由α-鼠胆酸(MCA)在细胞色素P450 3A4(CYP3A4)作用下合成。
Packaging
5 mL棕色玻璃螺旋盖样品瓶（700159P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
K Lundell et al.
The Journal of biological chemistry, 276(13), 9606-9612 (2000-12-23)
A cytochrome P450 expressed in pig liver was cloned by polymerase chain reaction using oligonucleotide primers based on amino acid sequences of the purified taurochenodeoxycholic acid 6alpha-hydroxylase. This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid, and the product hyocholic acid
Tammy L Kindel et al.
Surgical endoscopy, 32(2), 805-812 (2017-08-06)
Bile acids (BAs) are post-prandial hormones that play an important role in glucose and lipid homeostasis as well as energy expenditure. Total and glycine-amidated BAs increase after sleeve gastrectomy (SG) and correlate to improved metabolic disease. No specific bile acid
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