Product Name
链甾醇(D6)酯, 26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution
方案
>99% (TLC)
表单
methylene chloride solution
包装
pkg of 1 × 1 mL (700184M-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 700184M
浓度
1 mg/mL (700184M-1mg)
运输
dry ice
储存温度
−20°C
一般描述
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
生化/生理作用
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
包装
5 mL Clear Glass Sealed Ampule (700184M-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Warning
危险分类
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Central nervous system
WGK
WGK 2
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